Seroatlas · Human Serome Atlas

PLLP

Plasmolipin

Also known as: PLLP_HUMAN, PMLP, TM4SF11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y342
Gene
PLLP
Ensembl
ENSG00000102934
Chromosome
16
Canonical length
182 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Enables identical protein binding activity. Involved in myelin assembly and regulation of transcytosis. Located in myelin sheath and plasma membrane. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q9Y342|PLLP
     1  MAEFPSKVST RTSSPAQGAE ASVSALRPDL GFVRSRLGAL MLLQLVLGLL VWALIADTPY
    61  HLYPAYGWVM FVAVFLWLVT IVLFNLYLFQ LHMKLYMVPW PLVLMIFNIS ATVLYITAFI
   121  ACSAAVDLTS LRGTRPYNQR AAASFFACLV MIAYGVSAFF SYQAWRGVGS NAATSQMAGG
   181  YA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLLP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
200 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 200 nTPM
  • spinal cord: 186 nTPM
  • basal ganglia: 179 nTPM
  • midbrain: 173 nTPM
  • amygdala: 132 nTPM
  • hypothalamus: 107 nTPM

Single-cell type

  • oligodendrocytes: 358 nCPM
  • oligodendrocyte progenitor cells: 234 nCPM
  • alveolar cells type 1: 223 nCPM
  • endometrial luminal cells: 215 nCPM
  • enterocytes: 188 nCPM
  • epididymal clear cells: 186 nCPM

Immune cell

  • naive CD4 T-cell: 15 nTPM
  • naive CD8 T-cell: 5.7 nTPM
  • total PBMC: 2.2 nTPM
  • memory CD4 T-cell: 2.1 nTPM
  • neutrophil: 1.7 nTPM
  • basophil: 1.5 nTPM

Brain region

  • choroid plexus: 1,982 nTPM
  • thalamus: 1,641 nTPM
  • white matter: 1,527 nTPM
  • pons: 1,517 nTPM
  • medulla oblongata: 1,461 nTPM
  • cerebral cortex: 1,441 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0.01
gnomAD missense Z
0.87
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLLP as an antibody target. Whether an autoantibody or antibody against PLLP could matter depends on whether native PLLP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLLP is annotated at the cell surface, where native PLLP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLLP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLLP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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