Seroatlas · Human Serome Atlas

PLK5

Inactive serine/threonine-protein kinase PLK5

Also known as: PLK5_HUMAN, PLK5P, SgK384ps

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q496M5
Gene: PLK5
Ensembl: ENSG00000185988
Chromosome: 19
Canonical length: 336 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ATP binding activity and protein kinase activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q496M5|PLK5
     1  MYTVLTGTPP FMASPLSEMY QNIREGHYPE PAHLSANARR LIVHLLAPNP AERPSLDHLL
    61  QDDFFTQGFT PDRLPAHSCH SPPIFAIPPP LGRIFRKVGQ RLLTQCRPPC PFTPKEASGP
   121  GEGGPDPDSM EWDGESSLSA KEVPCLEGPI HLVAQGTLQS DLAGPEGSRR PEVEAALRHL
   181  QLCLDVGPPA TQDPLGEQQP ILWAPKWVDY SSKYGFGYQL LDGGRTGRHP HGPATPRREG
   241  TLPTPVPPAG PGLCLLRFLA SEHALLLLFS NGMVQVSFSG VPAQLVLSGE GEGLQLTLWE
   301  QGSPGTSYSL DVPRSHGCAP TTGQHLHHAL RMLQSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 32 nTPM
cervix: 8.9 nTPM
testis: 6.6 nTPM
basal ganglia: 5.4 nTPM
amygdala: 5 nTPM
cerebral cortex: 4.6 nTPM

Single-cell type

peritubular myoid cells: 116 nCPM
leydig cells: 77 nCPM
cardiomyocytes: 68 nCPM
myonuclei: 39 nCPM
müller glia: 39 nCPM
astrocytes: 31 nCPM

Immune cell

neutrophil: 0.8 nTPM
eosinophil: 0.5 nTPM
basophil: 0.3 nTPM
naive B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

cerebellum: 38 nTPM
hippocampal formation: 17 nTPM
cerebral cortex: 14 nTPM
amygdala: 13 nTPM
choroid plexus: 8.8 nTPM
basal ganglia: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLK5 as an antibody target. Whether an autoantibody or antibody against PLK5 could matter depends on whether native PLK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLK5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...