Seroatlas · Human Serome Atlas

PLGLB1

Plasminogen-like protein B

Also known as: PLGB_HUMAN, PLGL, PLGLB2, PLGP1, PRP-B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02325
Gene
PLGLB1
Ensembl
ENSG00000183281
Chromosome
2
Canonical length
96 aa
Protein class
Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>Q02325|PLGLB1
     1  MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG PSLFSVTKKQ LGAGSREECA AKCEEDKEFT
    61  CRAFQYHSKE QQCVIMAENR KSSIIIRMRD AVLFEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLGLB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • liver: 123 nTPM
  • retina: 2.5 nTPM
  • cerebellum: 1.7 nTPM
  • testis: 1.6 nTPM
  • spleen: 1.5 nTPM
  • ovary: 1.2 nTPM

Single-cell type

  • podocytes: 1.5 nCPM
  • loop of henle epithelial cells: 0.4 nCPM
  • brain inhibitory neurons: 0.3 nCPM
  • hepatocytes: 0.3 nCPM
  • nk-cells: 0.3 nCPM
  • other brain neurons: 0.3 nCPM

Immune cell

  • neutrophil: 0.4 nTPM
  • basophil: 0.3 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebellum: 6.5 nTPM
  • amygdala: 4.7 nTPM
  • cerebral cortex: 4.4 nTPM
  • basal ganglia: 4 nTPM
  • hippocampal formation: 3.8 nTPM
  • white matter: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0.07
gnomAD missense Z
0.99

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLGLB1 as an antibody target. Whether an autoantibody or antibody against PLGLB1 could matter depends on whether native PLGLB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLGLB1 is annotated as secreted, so native PLGLB1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLGLB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLGLB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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