Seroatlas · Human Serome Atlas

PLGLA

Plasminogen-like protein A

Also known as: PLGA_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15195
Gene: PLGLA
Canonical length: 96 aa

OverviewNCBI Gene

No narrative summary is available for PLGLA in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>Q15195|PLGLA
     1  MEHKEVVLLL LLFLKSGQGE PLDDYVNAQG ASLFSVTKKQ LGAGSREECA AKCEEDKEFT
    61  CRAFQYHSKE QQCVIMAENK KSSIIIRMRD VVLFEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLGLA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLGLA as an antibody target. Whether an autoantibody or antibody against PLGLA could matter depends on whether native PLGLA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLGLA is annotated as secreted, so native PLGLA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLGLA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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