Seroatlas · Human Serome Atlas

PLET1

Placenta-expressed transcript 1 protein

Also known as: C11orf34, PLET1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UQ28
Gene: PLET1
Ensembl: ENSG00000188771
Chromosome: 11
Canonical length: 207 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in negative regulation of cell-matrix adhesion; positive regulation of cell migration; and wound healing, spreading of epidermal cells. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in apical plasma membrane and external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q6UQ28|PLET1
     1  MAVFHDMLLQ PLGMFLCLSL QLSSATFIRY SSTCFTFDEY YTITLDIKAS SHIYESNAVY
    61  SVFVPVNDSV YAVVMKTLDE NSDSAGLWQR ADKNCYSNST YYVKDQYMTV LEAQWQAPEP
   121  ENITEVEIQA FTVQIRALPI LSTLKLREKL STLALAAKIP QSSAFKPFFM ITPKSIRLEG
   181  LANQVFSSPI TEAIYILLAF LTSTLLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLET1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

skin: 0.2 nTPM
bone marrow: 0.1 nTPM
pituitary gland: 0.1 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

epicardial cells: 61 nCPM
retinal ganglion cells: 35 nCPM
retinal horizontal cells: 32 nCPM
retinal bipolar cells: 25 nCPM
hepatic stellate cells: 19 nCPM
rod photoreceptor cells: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.9 nTPM
hypothalamus: 2.6 nTPM
pons: 2.3 nTPM
medulla oblongata: 2.1 nTPM
white matter: 2.1 nTPM
thalamus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.84

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Placenta-expressed transcript 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLET1 as an antibody target. Whether an autoantibody or antibody against PLET1 could matter depends on whether native PLET1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLET1 is annotated at the cell surface, where native PLET1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLET1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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