Seroatlas · Human Serome Atlas

PLEKHS1

Pleckstrin homology domain-containing family S member 1

Also known as: bA211N11.2, C10orf81, FLJ23537, PKHS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SXH7
Gene: PLEKHS1
Ensembl: ENSG00000148735
Chromosome: 10
Canonical length: 465 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Centrosome

OverviewNCBI Gene

No narrative summary is available for PLEKHS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q5SXH7|PLEKHS1
     1  MAGGKQFTFS YENEVCKQDY FIKSPPSQLF SSVTSWKKRF FILSKAGEKS FSLSYYKDHH
    61  HRGSIEIDQN SSVEVGISSQ EKMQSVQKMF KCHPDEVMSI RTTNREYFLI GHDREKIKDW
   121  VSFMSSFRQD IKATQQNTEE ELSLGNKRTL FYSSPLLGPS STSEAVGSSS PRNGLQDKHL
   181  MEQSSPGFRQ THLQDLSEAT QDVKEENHYL TPRSVLLELD NIIASSDSGE SIETDGPDQV
   241  SGRIECHYEP MESYFFKETS HESVDSSKEE PQTLPETQDG DLHLQEQGSG IDWCLSPADV
   301  EAQTTNDQKG NIPDESQVEK LNVFLSPPDV INYLALTEAT GRICVSQWEG PPRLGCIFCH
   361  GDHLLAVNDL KPQSLEEVSL FLTRSIQKED SFRILSYQVA FGEGTELRDR APGFRTSDRH
   421  DVAKRACMES DWCRDSKTAP STNLCLSFLF CKIMTNDGAG CWIIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

cervix: 46 nTPM
salivary gland: 40 nTPM
duodenum: 35 nTPM
small intestine: 31 nTPM
pancreas: 26 nTPM
breast: 23 nTPM

Single-cell type

respiratory secretory cells: 405 nCPM
respiratory deuterosomal cells: 361 nCPM
respiratory ciliated cells: 268 nCPM
salivary ionocytes: 146 nCPM
salivary duct cells: 144 nCPM
respiratory basal cells: 143 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.3 nTPM
medulla oblongata: 1.2 nTPM
white matter: 1.1 nTPM
thalamus: 0.9 nTPM
amygdala: 0.8 nTPM
basal ganglia: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Pleckstrin homology domain
PH-like domain superfamily
PH domain
Pleckstrin homology domain-containing family S member 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHS1 as an antibody target. Whether an autoantibody or antibody against PLEKHS1 could matter depends on whether native PLEKHS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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