Seroatlas · Human Serome Atlas

PLEKHM3

Pleckstrin homology domain-containing family M member 3

Also known as: DAPR, PKHM3_HUMAN, PLEKHM1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZWE6
Gene: PLEKHM3
Ensembl: ENSG00000178385
Chromosome: 2
Canonical length: 761 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in myoblast differentiation. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

761 residues, UniProt reviewed canonical sequence.

>Q6ZWE6|PLEKHM3
     1  MEALEVDDIS PALEVTEEFF STLDSNLEKA VQQAEVYGIQ EVPELVGHEV LSNITDNGAM
    61  RNVTSLGKGG MIWDHCKSRL LETKAQNVFP AKEQFMVQRG TTPDNLSWME QKEASTFNFF
   121  NICQRRRDRP RSVNDLLDET STFKPGHARS RSDITQVDWR VVLKTTPLQQ QQQQQPLLQG
   181  PHVTRPSFLL PSPNKIEDAQ GNTEHKQTFP NILKKGYLEI RKDHDSYWQS CYAELSPYNL
   241  YFYSLDSSGN QNLYATYQLS HFQSISVLGN LEARMVDTVL YDNTQLQLKA ESPWEALDWG
   301  QKLWEVVHAA VPGYMGRQNE LTISPGLGHH DDYTQNHSFQ KKTSGLLPPS PVLDSSKQYQ
   361  NILKSGTLYR LTVQNNWKAF TFVLSRAYLM AFQPGKLDED PLLSYNVDVC LAVQMDNLDG
   421  CDSCFQVIFP QDVLRLRAET RQRAQEWMEA LKIAANVARS SEQNLQVTLR NKPKDQMGGH
   481  ELRKNKRQSV TTSFLSILTT LSLERGLTAQ SFKCAGCQRS IGLSNGKAKV CNYSGWYYCS
   541  SCHVDDSFLI PARIVHNWDT SKYKVSKQAK EFLEYVYEEP LIDIQQENAM LYHHAEPLAA
   601  VLRLRQRLKS LRAYLFSCRA AVAEDLRRRI FPREYLLQQI HLYSLADLQQ VIEGKLAPFL
   661  GKVIKFATSH VYSCSLCSQK GFICEICNNG EILYPFEDIS TSRCESCGAV FHSECKEKSV
   721  PCPRCVRREL QKKQKSFWQR LNMDESLEEA CTMFELSYQN T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

retina: 7.7 nTPM
cerebral cortex: 4.9 nTPM
cerebellum: 4.4 nTPM
bone marrow: 4 nTPM
adrenal gland: 3.8 nTPM
parathyroid gland: 3.8 nTPM

Single-cell type

neutrophils: 243 nCPM
adrenal cortex cells: 182 nCPM
rod photoreceptor cells: 161 nCPM
cone photoreceptor cells: 153 nCPM
cdc: 129 nCPM
corticotrophs: 127 nCPM

Immune cell

neutrophil: 2.6 nTPM
basophil: 1.2 nTPM
naive CD4 T-cell: 1 nTPM
gdT-cell: 0.9 nTPM
memory B-cell: 0.9 nTPM
NK-cell: 0.9 nTPM

Brain region

midbrain: 22 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 21 nTPM
hypothalamus: 21 nTPM
pons: 20 nTPM
white matter: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 1.45
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

myoblast differentiation

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AKT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHM3 as an antibody target. Whether an autoantibody or antibody against PLEKHM3 could matter depends on whether native PLEKHM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHM3 is annotated at the cell surface, where native PLEKHM3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEKHM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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