Seroatlas · Human Serome Atlas

PLEKHH1

Pleckstrin homology domain-containing family H member 1

Also known as: KIAA1200, PKHH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULM0
Gene: PLEKHH1
Ensembl: ENSG00000054690
Chromosome: 14
Canonical length: 1364 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to be located in cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1364 residues, UniProt reviewed canonical sequence.

>Q9ULM0|PLEKHH1
     1  MAELKVEAPA SVDWQKRCLT LETQLFRFRL QASKIRELLA DKMQELEQRL LEAEQRAENA
    61  ETQVGVMEEK VKLSNLKNVD SEGSLHRKYQ ELLKAIKGKD ELISQLEAQL EKQKQMRAEE
   121  AKTVQEKAAK IKEWVTLKLA KLEMENQHLK SHNQRLVEQV GSLQDALEAI QIAPSRKLLV
   181  PPYGAAEQDS VPSEPGIQPM GQDSGSQAQG LKAAVLAPSP GALQSKDSVS EAASPLEDSS
   241  SSTVHSGETV EAKPLQPHLG RESPPHQPCM KLLTFRCSSA SWGEGLVTAQ RGMLPGTKTS
   301  AREGGPGSSL TLPKVRAPGT PRDSIQLAKR HHSQPQVGHG HFGRVVNIET EAFSALHPSG
   361  LPELESRARS REEPEKMEME EPPPAGKNEE RESPKALGAE LEEVELGNKP PTPPLHQFSS
   421  WESRIYAVAT SGMRLSDMSP RSNTACCASS PPALVSPGSF SGLVYKNVTV PVYTALKGRA
   481  TQISNMPFMD ESSGSDDDCS SQASFRISVP SSESRKTSGL GSPRAIKRGV SMSSLSSEGD
   541  YAIPPDACSL DSDYSEPEHK LQRTSSYSTD GLGLGGESLE KSGYLLKMGS QVKTWKRRWF
   601  VLRQGQIMYY KSPSDVIRKP QGQVDLNSRC QIVRGEGSQT FQLISEKKTY YLTADSPSLL
   661  EEWIRVLQSL LKVQATGPPA LLRGGTKPTV KGWLTKVKHG HSKVVWCALV GKIFYYYRSH
   721  EDKRPLGCLP VRDAHIEEVD RSCDSDEDYE AGGTRRLLSS HCTLVIHPTE HSPTYLLIGT
   781  KHEKDTWLYH LTVAAGGSSA KVGTAYEQLI GKLMDGEGDP DSPLWRHPML CYSKDGLYAS
   841  LTTLPSEALQ TEALKLFKSC QLFINVPVEA ASVDYHVSLA QTALQVCLVH PELQSEIYCQ
   901  LMKQTSCRPP QKYSLMQCWQ LLALCAPLFL PQHHFLWYVK QQLQRHADPR SETGQYATYC
   961  QRAVERTLRT GEREARPSRM EVVSILLRNP FHHSLPFSIP VHFTNGTYHV VGFDGSSTVD
  1021  EFLQRLNQEI GMRKPSHSGF ALFTDDPSGR DLEHCLQGSV KICDAISKWE QAMKELHPGK
  1081  SEGGTRVVKL MYKNRLYFRS QVKGETDRER LLLASQTSRE IVAGRFPINK ELALEMAALM
  1141  AQVEYGDLEK PALPGPGGTS PAKAQHLLQQ VLDRFHPRRY RHGAPAEQLR HLADMLTTKW
  1201  ATLQGCSPPE CIRIYLTVAR KWPFFGAKLF AAQPAQLSSK ENALVWIAVN EDGVSILDHN
  1261  TMQVHITYPY SSVTTFGGCR DDFMLVIRSI PDKSSGKSHI EKLIFRMAAP KIAEATFIMA
  1321  SYMNHCTTTV NPPTNPPGAC QLWELDGRQF FSSVSCATKG PTLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 42 nTPM
thyroid gland: 35 nTPM
cerebral cortex: 24 nTPM
salivary gland: 22 nTPM
hippocampal formation: 18 nTPM
midbrain: 17 nTPM

Single-cell type

oligodendrocytes: 855 nCPM
retinal pigment epithelial cells: 239 nCPM
pituitary stem cells: 169 nCPM
salivary acinar cells: 110 nCPM
cone photoreceptor cells: 110 nCPM
prostatic glandular cells: 101 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 351 nTPM
medulla oblongata: 199 nTPM
basal ganglia: 180 nTPM
cerebral cortex: 160 nTPM
midbrain: 157 nTPM
thalamus: 156 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 1.96
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoskeleton

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHH1 as an antibody target. Whether an autoantibody or antibody against PLEKHH1 could matter depends on whether native PLEKHH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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