Seroatlas · Human Serome Atlas

PLEKHB2

Pleckstrin homology domain-containing family B member 2

Also known as: EVT2, FLJ20783, PKHB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CS7
Gene: PLEKHB2
Ensembl: ENSG00000115762
Chromosome: 2
Canonical length: 222 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in recycling endosome membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q96CS7|PLEKHB2
     1  MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP MDCINIRTGQ
    61  ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT
   121  DETSVVSSPP PYTAYAAPAP EQAYGYGPYG GAYPPGTQVV YAANGQAYAV PYQYPYAGLY
   181  GQQPANQVII RERYRDNDSD LALGMLAGAA TGMALGSLFW VF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

kidney: 114 nTPM
parathyroid gland: 87 nTPM
retina: 82 nTPM
cerebral cortex: 76 nTPM
bone marrow: 65 nTPM
rectum: 62 nTPM

Single-cell type

parietal cells: 347 nCPM
endometrial glandular cells: 331 nCPM
endometrial luminal cells: 304 nCPM
neutrophils: 242 nCPM
epididymal clear cells: 235 nCPM
monocytes: 219 nCPM

Immune cell

non-classical monocyte: 79 nTPM
intermediate monocyte: 71 nTPM
classical monocyte: 56 nTPM
myeloid DC: 54 nTPM
total PBMC: 49 nTPM
neutrophil: 34 nTPM

Brain region

pons: 157 nTPM
hypothalamus: 139 nTPM
midbrain: 136 nTPM
medulla oblongata: 122 nTPM
white matter: 116 nTPM
cerebellum: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of cell differentiation

Molecular functions

5-trisphosphate binding
phosphatidylinositol-3
4

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHB2 as an antibody target. Whether an autoantibody or antibody against PLEKHB2 could matter depends on whether native PLEKHB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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