Seroatlas · Human Serome Atlas

PLEKHA8P1

Putative protein PLEKHA9

Also known as: PKHA9_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95397
Gene: PLEKHA8P1
Canonical length: 391 aa

OverviewNCBI Gene

No narrative summary is available for PLEKHA8P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>O95397|PLEKHA8P1
     1  MSELRLCCDL LVQQVDKTKE VTTTGVSNSE EGIDVGTLLK STCNTFLKTL EECMQIANAA
    61  FTSELLYHTP PGSPQLAMLK SSKMKHPIIP IHNSLERQTE LSTCENGSLN MEINGEEEIL
   121  MKNKNSLYLK SAEIDCSISS EENTDDNITV QGEIMKEDRM ENLKNHDNNL SQSGSDSSCS
   181  PECLWEEGKE VIPTFFSTMN TSFSDIELLE DSGIPTEAFL ASCCAVVPVL DKLGPTVFAP
   241  VKMDLVENIK KVNQKYITNK EEFTTLQKIV LHEVEADVAQ VRNSATEALL WLKRGLKFLK
   301  GFLTEVKNGE KDIQTALNNA YGKTLRQHHG WVVRGVFALA LRATPSYEDF VAALTVKEGD
   361  HRKEAFSIGM QRDLSLYLPA MKKQMAILDA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHA8P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHA8P1 as an antibody target. Whether an autoantibody or antibody against PLEKHA8P1 could matter depends on whether native PLEKHA8P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHA8P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHA8P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...