Seroatlas · Human Serome Atlas

PLEKHA6

Pleckstrin homology domain-containing family A member 6

Also known as: KIAA0969, PEPP3, PKHA6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2H5
Gene: PLEKHA6
Ensembl: ENSG00000143850
Chromosome: 1
Canonical length: 1048 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cell Junctions

OverviewNCBI Gene

No narrative summary is available for PLEKHA6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1048 residues, UniProt reviewed canonical sequence.

>Q9Y2H5|PLEKHA6
     1  MSNKTGGKRP ATTNSDIPNH NMVSEVPPER PSVRATRTAR KAVAFGKRSH SMKRNPNAPV
    61  TKAGWLFKQA SSGVKQWNKR WFVLVDRCLF YYKDEKEESI LGSIPLLSFR VAAVQPSDNI
   121  SRKHTFKAEH AGVRTYFFSA ESPEEQEAWI QAMGEAARVQ IPPAQKSVPQ AVRHSHEKPD
   181  SENVPPSKHH QQPPHNSLPK PEPEAKTRGE GDGRGCEKAE RRPERPEVKK EPPVKANGLP
   241  AGPEPASEPG SPYPEGPRVP GGGEQPAQPN GWQYHSPSRP GSTAFPSQDG ETGGHRRSFP
   301  PRTNPDKIAQ RKSSMNQLQQ WVNLRRGVPP PEDLRSPSRF YPVSRRVPEY YGPYSSQYPD
   361  DYQYYPPGVR PESICSMPAY DRISPPWALE DKRHAFRNGG GPAYQLREWK EPASYGRQDA
   421  TVWIPSPSRQ PVYYDELDAA SSSLRRLSLQ PRSHSVPRSP SQGSYSRARI YSPVRSPSAR
   481  FERLPPRSED IYADPAAYVM RRSISSPKVP PYPEVFRDSL HTYKLNEQDT DKLLGKLCEQ
   541  NKVVREQDRL VQQLRAEKES LESALMGTHQ ELEMFGSQPA YPEKLRHKKD SLQNQLINIR
   601  VELSQATTAL TNSTIEYEHL ESEVSALHDD LWEQLNLDTQ NEVLNRQIQK EIWRIQDVME
   661  GLRKNNPSRG TDTAKHRGGL GPSATYSSNS PASPLSSASL TSPLSPFSLV SGSQGSPTKP
   721  GSNEPKANYE QSKKDPHQTL PLDTPRDISL VPTRQEVEAE KQAALNKVGV VPPRTKSPTD
   781  DEVTPSAVVR RNASGLTNGL SSQERPKSAV FPGEGKVKMS VEEQIDRMRR HQSGSMREKR
   841  RSLQLPASPA PDPSPRPAYK VVRRHRSIHE VDISNLEAAL RAEEPGGHAY ETPREEIARL
   901  RKMELEPQHY DVDINKELST PDKVLIPERY IDLEPDTPLS PEELKEKQKK VERIKTLIAK
   961  SSMQNVVPIG EGDSVDVPQD SESQLQEQEK RIEISCALAT EASRRGRMLS VQCATPSPPT
  1021  SPASPAPPAN PLSSESPRGA DSSYTMRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

stomach: 38 nTPM
cerebellum: 33 nTPM
spinal cord: 32 nTPM
colon: 30 nTPM
pituitary gland: 30 nTPM
cerebral cortex: 29 nTPM

Single-cell type

proximal tubule cells: 565 nCPM
esophageal apical cells: 281 nCPM
retinal amacrine cells: 272 nCPM
thyrotrophs: 220 nCPM
retinal bipolar cells: 217 nCPM
lactotrophs: 216 nCPM

Immune cell

memory B-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

thalamus: 114 nTPM
cerebral cortex: 108 nTPM
midbrain: 91 nTPM
pons: 89 nTPM
medulla oblongata: 88 nTPM
white matter: 86 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.01
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHA6 as an antibody target. Whether an autoantibody or antibody against PLEKHA6 could matter depends on whether native PLEKHA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHA6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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