Seroatlas · Human Serome Atlas

PLD5

Inactive phospholipase D5

Also known as: FLJ40773, PLD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7P1
Gene: PLD5
Ensembl: ENSG00000180287
Chromosome: 1
Canonical length: 536 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable catalytic activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>Q8N7P1|PLD5
     1  MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS ASVWLRRKDK
    61  LEHSQQKCIV IFALVCCFAI LVALIFSAVD IMGEDEDGLS EKNCQNKCRI ALVENIPEGL
   121  NYSENAPFHL SLFQGWMNLL NMAKKSVDIV SSHWDLNHTH PSACQGQRLF EKLLQLTSQN
   181  IEIKLVSDVT ADSKVLEALK LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW
   241  QSLGQMKELG VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ
   301  LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVMDYLPI SSTSTKRTYW
   361  PDLDAKIREA LVLRSVRVRL LLSFWKETDP LTFNFISSLK AICTEIANCS LKVKFFDLER
   421  ENACATKEQK NHTFPRLNRN KYMVTDGAAY IGNFDWVGND FTQNAGTGLV INQADVRNNR
   481  SIIKQLKDVF ERDWYSPYAK TLQPTKQPNC SSLFKLKPLS NKTATDDTGG KDPRNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 26 nTPM
blood vessel: 11 nTPM
cerebellum: 7 nTPM
spinal cord: 3.3 nTPM
seminal vesicle: 2.8 nTPM
amygdala: 2.3 nTPM

Single-cell type

choroid plexus epithelial cells: 2,656 nCPM
retinal pigment epithelial cells: 1,957 nCPM
gonadotrophs: 698 nCPM
oligodendrocytes: 271 nCPM
brain inhibitory neurons: 264 nCPM
salivary myoepithelial cells: 236 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 117 nTPM
cerebellum: 35 nTPM
hippocampal formation: 8.4 nTPM
medulla oblongata: 7.1 nTPM
pons: 7 nTPM
basal ganglia: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.03
gnomAD missense Z: 1.54
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

catalytic activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLD5 as an antibody target. Whether an autoantibody or antibody against PLD5 could matter depends on whether native PLD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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