Seroatlas · Human Serome Atlas

PLD4

5'-3' exonuclease PLD4

Also known as: C14orf175, PLD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BZ4
Gene
PLD4
Ensembl
ENSG00000166428
Chromosome
14
Canonical length
506 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>Q96BZ4|PLD4
     1  MLKPLWKAAV APTWPCSMPP RRPWDREAGT LQVLGALAVL WLGSVALICL LWQVPRPPTW
    61  GQVQPKDVPR SWEHGSSPAW EPLEAEARQQ RDSCQLVLVE SIPQDLPSAA GSPSAQPLGQ
   121  AWLQLLDTAQ ESVHVASYYW SLTGPDIGVN DSSSQLGEAL LQKLQQLLGR NISLAVATSS
   181  PTLARTSTDL QVLAARGAHV RQVPMGRLTR GVLHSKFWVV DGRHIYMGSA NMDWRSLTQV
   241  KELGAVIYNC SHLAQDLEKT FQTYWVLGVP KAVLPKTWPQ NFSSHFNRFQ PFHGLFDGVP
   301  TTAYFSASPP ALCPQGRTRD LEALLAVMGS AQEFIYASVM EYFPTTRFSH PPRYWPVLDN
   361  ALRAAAFGKG VRVRLLVGCG LNTDPTMFPY LRSLQALSNP AANVSVDVKV FIVPVGNHSN
   421  IPFSRVNHSK FMVTEKAAYI GTSNWSEDYF SSTAGVGLVV TQSPGAQPAG ATVQEQLRQL
   481  FERDWSSRYA VGLDGQAPGQ DCVWQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 18 nTPM
  • midbrain: 16 nTPM
  • bone marrow: 13 nTPM
  • lymph node: 11 nTPM
  • spleen: 9.8 nTPM
  • amygdala: 9.3 nTPM

Single-cell type

  • pdcs: 616 nCPM
  • microglia: 136 nCPM
  • cdc: 42 nCPM
  • macrophages: 39 nCPM
  • hofbauer cells: 34 nCPM
  • epicardial cells: 25 nCPM

Immune cell

  • plasmacytoid DC: 3,629 nTPM
  • eosinophil: 701 nTPM
  • myeloid DC: 547 nTPM
  • non-classical monocyte: 299 nTPM
  • memory B-cell: 224 nTPM
  • naive B-cell: 199 nTPM

Brain region

  • white matter: 42 nTPM
  • medulla oblongata: 39 nTPM
  • spinal cord: 36 nTPM
  • pons: 28 nTPM
  • thalamus: 26 nTPM
  • hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.3
gnomAD pLI
0
gnomAD missense Z
-0.17
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLD4 as an antibody target. Whether an autoantibody or antibody against PLD4 could matter depends on whether native PLD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLD4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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