Seroatlas · Human Serome Atlas

PLBD2

Putative phospholipase B-like 2

Also known as: p76, PLBL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHP8
Gene: PLBD2
Ensembl: ENSG00000151176
Chromosome: 12
Canonical length: 589 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>Q8NHP8|PLBD2
     1  MVGQMYCYPG SHLARALTRA LALALVLALL VGPFLSGLAG AIPAPGGRWA RDGQVPPASR
    61  SRSVLLDVSA GQLLMVDGRH PDAVAWANLT NAIRETGWAF LELGTSGQYN DSLQAYAAGV
   121  VEAAVSEELI YMHWMNTVVN YCGPFEYEVG YCERLKSFLE ANLEWMQEEM ESNPDSPYWH
   181  QVRLTLLQLK GLEDSYEGRV SFPAGKFTIK PLGFLLLQLS GDLEDLELAL NKTKIKPSLG
   241  SGSCSALIKL LPGQSDLLVA HNTWNNYQHM LRVIKKYWLQ FREGPWGDYP LVPGNKLVFS
   301  SYPGTIFSCD DFYILGSGLV TLETTIGNKN PALWKYVRPR GCVLEWVRNI VANRLASDGA
   361  TWADIFKRFN SGTYNNQWMI VDYKAFIPGG PSPGSRVLTI LEQIPGMVVV ADKTSELYQK
   421  TYWASYNIPS FETVFNASGL QALVAQYGDW FSYDGSPRAQ IFRRNQSLVQ DMDSMVRLMR
   481  YNDFLHDPLS LCKACNPQPN GENAISARSD LNPANGSYPF QALRQRSHGG IDVKVTSMSL
   541  ARILSLLAAS GPTWDQVPPF QWSTSPFSGL LHMGQPDLWK FAPVKVSWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLBD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 131 nTPM
testis: 48 nTPM
ovary: 42 nTPM
blood vessel: 33 nTPM
heart muscle: 30 nTPM
hypothalamus: 27 nTPM

Single-cell type

late spermatids: 849 nCPM
early spermatids: 168 nCPM
adrenal cortex cells: 120 nCPM
somatotrophs: 83 nCPM
peritubular myoid cells: 53 nCPM
monocytes: 51 nCPM

Immune cell

classical monocyte: 3.5 nTPM
myeloid DC: 3.5 nTPM
intermediate monocyte: 2.1 nTPM
total PBMC: 2 nTPM
memory CD8 T-cell: 1.5 nTPM
non-classical monocyte: 1.5 nTPM

Brain region

medulla oblongata: 117 nTPM
pons: 114 nTPM
thalamus: 106 nTPM
midbrain: 93 nTPM
hypothalamus: 88 nTPM
cerebellum: 82 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 1.2
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phospholipid catabolic process

Molecular functions

phospholipase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLBD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IGF2R

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLBD2 as an antibody target. Whether an autoantibody or antibody against PLBD2 could matter depends on whether native PLBD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLBD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLBD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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