Seroatlas · Human Serome Atlas

PLBD1

Phospholipase B-like 1

Also known as: FLJ22662, PLBL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P4A8
Gene: PLBD1
Ensembl: ENSG00000121316
Chromosome: 12
Canonical length: 553 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q6P4A8|PLBD1
     1  MTRGGPGGRP GLPQPPPLLL LLLLLPLLLV TAEPPKPAGV YYATAYWMPA EKTVQVKNVM
    61  DKNGDAYGFY NNSVKTTGWG ILEIRAGYGS QTLSNEIIMF VAGFLEGYLT APHMNDHYTN
   121  LYPQLITKPS IMDKVQDFME KQDKWTRKNI KEYKTDSFWR HTGYVMAQID GLYVGAKKRA
   181  ILEGTKPMTL FQIQFLNSVG DLLDLIPSLS PTKNGSLKVF KRWDMGHCSA LIKVLPGFEN
   241  ILFAHSSWYT YAAMLRIYKH WDFNVIDKDT SSSRLSFSSY PGFLESLDDF YILSSGLILL
   301  QTTNSVFNKT LLKQVIPETL LSWQRVRVAN MMADSGKRWA DIFSKYNSGT YNNQYMVLDL
   361  KKVKLNHSLD KGTLYIVEQI PTYVEYSEQT DVLRKGYWPS YNVPFHEKIY NWSGYPLLVQ
   421  KLGLDYSYDL APRAKIFRRD QGKVTDTASM KYIMRYNNYK KDPYSRGDPC NTICCREDLN
   481  SPNPSPGGCY DTKVADIYLA SQYTSYAISG PTVQGGLPVF RWDRFNKTLH QGMPEVYNFD
   541  FITMKPILKL DIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLBD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 270 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 270 nTPM
rectum: 74 nTPM
choroid plexus: 72 nTPM
lung: 60 nTPM
colon: 55 nTPM
urinary bladder: 55 nTPM

Single-cell type

neutrophil progenitors: 1,094 nCPM
esophageal apical cells: 691 nCPM
neutrophils: 610 nCPM
monocytes: 301 nCPM
extravillous trophoblasts: 262 nCPM
monocyte progenitors: 197 nCPM

Immune cell

classical monocyte: 663 nTPM
neutrophil: 445 nTPM
total PBMC: 423 nTPM
myeloid DC: 358 nTPM
intermediate monocyte: 204 nTPM
non-classical monocyte: 74 nTPM

Brain region

choroid plexus: 51 nTPM
white matter: 7.9 nTPM
medulla oblongata: 5.5 nTPM
pons: 4.7 nTPM
spinal cord: 4.5 nTPM
thalamus: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLBD1 as an antibody target. Whether an autoantibody or antibody against PLBD1 could matter depends on whether native PLBD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLBD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLBD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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