PLAC8L1
PLAC8-like protein 1
Also known as: PL8L1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A1L4L8
- Gene
- PLAC8L1
- Ensembl
- ENSG00000173261
- Chromosome
- 5
- Canonical length
- 177 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for PLAC8L1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
177 residues, UniProt reviewed canonical sequence.
>A1L4L8|PLAC8L1
1 MNWFGSNFFR CPEDLSLLNI YSPLLSHMSS EDEHFISNLR GHVPASAVVK QPVRGASGRT
61 TITAIVQTGG GWSTGLFSVC RDRRICFCGL FCPMCLECDI ARHYGECLCW PLLPGSTFAL
121 RIGTRERHKI QGTLCEDWLA VHCCWAFSIC QVARELKMRT SQVYEICAVP MTKDTLVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PLAC8L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 5.7 nTPM
Expression across tissuesHPA
Tissue
- testis: 5.7 nTPM
- cerebellum: 1.2 nTPM
- spinal cord: 0.9 nTPM
- basal ganglia: 0.7 nTPM
- skin: 0.7 nTPM
- cerebral cortex: 0.6 nTPM
Single-cell type
- early spermatids: 563 nCPM
- late spermatids: 389 nCPM
- late primary spermatocytes: 180 nCPM
- adrenal medulla cells: 43 nCPM
- epicardial cells: 25 nCPM
- endometrial secretory cells: 16 nCPM
Immune cell
- T-reg: 0.3 nTPM
- plasmacytoid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebellum: 3.6 nTPM
- cerebral cortex: 3.1 nTPM
- white matter: 3.1 nTPM
- basal ganglia: 2.6 nTPM
- hippocampal formation: 2.5 nTPM
- hypothalamus: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.31
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.86
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PLAC8L1 as an antibody target. Whether an autoantibody or antibody against PLAC8L1 could matter depends on whether native PLAC8L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PLAC8L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PLAC8L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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