PLAC8
Placenta-specific gene 8 protein
Also known as: C15, onzin, PLAC8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NZF1
- Gene
- PLAC8
- Ensembl
- ENSG00000145287
- Chromosome
- 4
- Canonical length
- 115 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>Q9NZF1|PLAC8
1 MQAQAPVVVV TQPGVGPGPA PQNSNWQTGM CDCFSDCGVC LCGTFCFPCL GCQVAADMNE
61 CCLCGTSVAM RTLYRTRYGI PGSICDDYMA TLCCPHCTLC QIKRDINRRR AMRTFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PLAC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 346 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 346 nTPM
- colon: 221 nTPM
- rectum: 153 nTPM
- spleen: 149 nTPM
- tonsil: 129 nTPM
- stomach: 111 nTPM
Single-cell type
- esophageal apical cells: 2,724 nCPM
- colonocytes: 1,934 nCPM
- extravillous trophoblasts: 968 nCPM
- pdcs: 851 nCPM
- respiratory secretory cells: 736 nCPM
- foveolar cells: 726 nCPM
Immune cell
- plasmacytoid DC: 2,328 nTPM
- NK-cell: 1,061 nTPM
- intermediate monocyte: 640 nTPM
- total PBMC: 580 nTPM
- memory B-cell: 528 nTPM
- naive B-cell: 485 nTPM
Brain region
- medulla oblongata: 27 nTPM
- pons: 21 nTPM
- white matter: 17 nTPM
- midbrain: 15 nTPM
- cerebral cortex: 15 nTPM
- spinal cord: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.17
- gnomAD pLI
- 0.12
- gnomAD missense Z
- 1.06
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- brown fat cell differentiation
- defense response to bacterium
- negative regulation of apoptotic process
- negative regulation of multicellular organism growth
- positive regulation of cell population proliferation
- positive regulation of cold-induced thermogenesis
- positive regulation of transcription by RNA polymerase II
- response to cold
- transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PLAC8 as an antibody target. Whether an autoantibody or antibody against PLAC8 could matter depends on whether native PLAC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PLAC8 is annotated as secreted, so native PLAC8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PLAC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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