Seroatlas · Human Serome Atlas

PLAAT5

Phospholipase A and acyltransferase 5

Also known as: HRASLS5, HRLP5, iNAT, PLAAT-5, PLAT5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KN8
Gene: PLAAT5
Ensembl: ENSG00000168004
Chromosome: 11
Canonical length: 279 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>Q96KN8|PLAAT5
     1  MGLSPGAEGE YALRLPRIPP PLPKPASRTA STGPKDQPPA LRRSAVPHSG LNSISPLELE
    61  ESVGFAALVQ LPAKQPPPGT LEQGRSIQQG EKAVVSLETT PSQKADWSSI PKPENEGKLI
   121  KQAAEGKPRP RPGDLIEIFR IGYEHWAIYV EDDCVVHLAP PSEEFEVGSI TSIFSNRAVV
   181  KYSRLEDVLH GCSWKVNNKL DGTYLPLPVD KIIQRTKKMV NKIVQYSLIE GNCEHFVNGL
   241  RYGVPRSQQV EHALMEGAKA AGAVISAVVD SIKPKPITA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLAAT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

testis: 52 nTPM
adipose tissue: 16 nTPM
pancreas: 13 nTPM
breast: 3.3 nTPM
spinal cord: 3.3 nTPM
seminal vesicle: 1.3 nTPM

Single-cell type

late spermatids: 1,549 nCPM
early spermatids: 418 nCPM
late primary spermatocytes: 361 nCPM
adipocytes: 68 nCPM
sertoli cells: 44 nCPM
mesothelial cells: 32 nCPM

Immune cell

eosinophil: 16 nTPM
basophil: 5.4 nTPM
memory CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 8.8 nTPM
medulla oblongata: 5.5 nTPM
hypothalamus: 5.1 nTPM
amygdala: 4.6 nTPM
spinal cord: 4.4 nTPM
cerebral cortex: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

N-acylphosphatidylethanolamine metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLAAT5 as an antibody target. Whether an autoantibody or antibody against PLAAT5 could matter depends on whether native PLAAT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLAAT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLAAT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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