Seroatlas · Human Serome Atlas

PLAAT4

Phospholipase A and acyltransferase 4

Also known as: HRASLS4, PLAAT-4, PLAT4_HUMAN, RARRES3, RIG1, TIG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UL19
Gene
PLAAT4
Ensembl
ENSG00000133321
Chromosome
11
Canonical length
164 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q9UL19|PLAAT4
     1  MASPHQEPKP GDLIEIFRLG YEHWALYIGD GYVIHLAPPS EYPGAGSSSV FSVLSNSAEV
    61  KRERLEDVVG GCCYRVNNSL DHEYQPRPVE VIISSAKEMV GQKMKYSIVS RNCEHFVTQL
   121  RYGKSRCKQV EKAKVEVGVA TALGILVVAG CSFAIRRYQK KATA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLAAT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
190 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 190 nTPM
  • lung: 104 nTPM
  • liver: 101 nTPM
  • breast: 96 nTPM
  • small intestine: 96 nTPM
  • fallopian tube: 93 nTPM

Single-cell type

  • enterocytes: 532 nCPM
  • epididymal clear cells: 414 nCPM
  • salivary ionocytes: 358 nCPM
  • alveolar cells type 1: 345 nCPM
  • epididymal efferent duct ciliated cells: 298 nCPM
  • respiratory secretory cells: 272 nCPM

Immune cell

  • total PBMC: 563 nTPM
  • memory CD8 T-cell: 454 nTPM
  • gdT-cell: 428 nTPM
  • naive CD8 T-cell: 372 nTPM
  • MAIT T-cell: 329 nTPM
  • memory CD4 T-cell: 325 nTPM

Brain region

  • medulla oblongata: 57 nTPM
  • hypothalamus: 41 nTPM
  • white matter: 38 nTPM
  • thalamus: 33 nTPM
  • pons: 30 nTPM
  • amygdala: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLAAT4 as an antibody target. Whether an autoantibody or antibody against PLAAT4 could matter depends on whether native PLAAT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLAAT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLAAT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLAAT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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