Seroatlas · Human Serome Atlas

PLAAT3

Phospholipase A and acyltransferase 3

Also known as: AdPLA, H-REV107-1, HRASLS3, HREV107, HREV107-3, MGC118754., PLA2G16, PLAAT-3, PLAT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53816
Gene
PLAAT3
Ensembl
ENSG00000176485
Chromosome
11
Canonical length
162 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Subcellular location
Mitochondria,Cytosol

OverviewNCBI Gene

Enables N-acyltransferase activity; lipid binding activity; and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

162 residues, UniProt reviewed canonical sequence.

>P53816|PLAAT3
     1  MRAPIPEPKP GDLIEIFRPF YRHWAIYVGD GYVVHLAPPS EVAGAGAASV MSALTDKAIV
    61  KKELLYDVAG SDKYQVNNKH DDKYSPLPCS KIIQRAEELV GQEVLYKLTS ENCEHFVNEL
   121  RYGVARSDQV RDVIIAASVA GMGLAAMSLI GVMFSRNKRQ KQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLAAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
319 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 319 nTPM
  • adipose tissue: 299 nTPM
  • midbrain: 214 nTPM
  • breast: 171 nTPM
  • hippocampal formation: 156 nTPM
  • basal ganglia: 133 nTPM

Single-cell type

  • migrating cytotrophoblasts: 519 nCPM
  • granulosa cells: 489 nCPM
  • extravillous trophoblasts: 466 nCPM
  • adipocytes: 396 nCPM
  • endometrial glandular cells: 360 nCPM
  • oligodendrocytes: 348 nCPM

Immune cell

  • plasmacytoid DC: 188 nTPM
  • gdT-cell: 55 nTPM
  • memory CD8 T-cell: 41 nTPM
  • MAIT T-cell: 30 nTPM
  • naive CD8 T-cell: 30 nTPM
  • total PBMC: 27 nTPM

Brain region

  • white matter: 577 nTPM
  • medulla oblongata: 369 nTPM
  • basal ganglia: 368 nTPM
  • midbrain: 299 nTPM
  • pons: 296 nTPM
  • spinal cord: 286 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLAAT3.

Disease | AllUniProt

Conditions PLAAT3 is implicated in, by any mechanism.

  • Lipodystrophy, familial partial, 9 (FPLD9) MIM:620683

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Lipodystrophy, familial partial, type 9

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLAAT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLAAT3 as an antibody target. Whether an autoantibody or antibody against PLAAT3 could matter depends on whether native PLAAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLAAT3 is annotated at the cell surface, where native PLAAT3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLAAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLAAT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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