Seroatlas · Human Serome Atlas

PLA2G5

Phospholipase A2 group V

Also known as: PA2G5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P39877
Gene
PLA2G5
Ensembl
ENSG00000127472
Chromosome
1
Canonical length
138 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>P39877|PLA2G5
     1  MKGLLPLAWF LACSVPAVQG GLLDLKSMIE KVTGKNALTN YGFYGCYCGW GGRGTPKDGT
    61  DWCCWAHDHC YGRLEEKGCN IRTQSYKYRF AWGVVTCEPG PFCHVNLCAC DRKLVYCLKR
   121  NLRSYNPQYQ YFPNILCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 56 nTPM
  • heart muscle: 46 nTPM
  • blood vessel: 22 nTPM
  • retina: 18 nTPM
  • colon: 15 nTPM
  • ovary: 11 nTPM

Single-cell type

  • retinal pigment epithelial cells: 371 nCPM
  • leydig cells: 321 nCPM
  • cone photoreceptor cells: 296 nCPM
  • hepatic stellate cells: 258 nCPM
  • peritubular myoid cells: 244 nCPM
  • pericytes: 235 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • thalamus: 9.2 nTPM
  • basal ganglia: 7.8 nTPM
  • midbrain: 7.8 nTPM
  • cerebellum: 7.1 nTPM
  • medulla oblongata: 6.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLA2G5.

Disease | AllUniProt

Conditions PLA2G5 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 135 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
gnomAD missense Z
0.27
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G5 as an antibody target. Whether an autoantibody or antibody against PLA2G5 could matter depends on whether native PLA2G5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G5 is annotated at the cell surface, where native PLA2G5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLA2G5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLA2G5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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