Seroatlas · Human Serome Atlas

PLA2G3

Group 3 secretory phospholipase A2

Also known as: GIII-SPLA2, PA2G3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZ20
Gene
PLA2G3
Ensembl
ENSG00000100078
Chromosome
22
Canonical length
509 aa
Protein class
Enzymes, Metabolic proteins, Predicted secreted proteins, RAS pathway related proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>Q9NZ20|PLA2G3
     1  MGVQAGLFGM LGFLGVALGG SPALRWYRTS CHLTKAVPGN PLGYLSFLAK DAQGLALIHA
    61  RWDAHRRLQS CSWEDEPELT AAYGALCAHE TAWGSFIHTP GPELQRALAT LQSQWEACRA
   121  LEESPAGARK KRAAGQSGVP GGGHQREKRG WTMPGTLWCG VGDSAGNSSE LGVFQGPDLC
   181  CREHDRCPQN ISPLQYNYGI RNYRFHTISH CDCDTRFQQC LQNQHDSISD IVGVAFFNVL
   241  EIPCFVLEEQ EACVAWYWWG GCRMYGTVPL ARLQPRTFYN ASWSSRATSP TPSSRSPAPP
   301  KPRQKQHLRK GPPHQKGSKR PSKANTTALQ DPMVSPRLDV APTGLQGPQG GLKPQGARWV
   361  CRSFRRHLDQ CEHQIGPREI EFQLLNSAQE PLFHCNCTRR LARFLRLHSP PEVTNMLWEL
   421  LGTTCFKLAP PLDCVEGKNC SRDPRAIRVS ARHLRRLQQR RHQLQDKGTD ERQPWPSEPL
   481  RGPMSFYNQC LQLTQAARRP DRQQKSWSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • skin: 15 nTPM
  • esophagus: 14 nTPM
  • vagina: 7.2 nTPM
  • cervix: 5 nTPM
  • choroid plexus: 2.5 nTPM
  • lung: 2.4 nTPM

Single-cell type

  • breast lactating cells: 107 nCPM
  • esophageal suprabasal cells: 27 nCPM
  • suprabasal keratinocytes: 21 nCPM
  • esophageal apical cells: 17 nCPM
  • alveolar cells type 2: 16 nCPM
  • tuft cells: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 3.7 nTPM
  • cerebellum: 1.9 nTPM
  • choroid plexus: 1.7 nTPM
  • medulla oblongata: 1.6 nTPM
  • hippocampal formation: 1 nTPM
  • cerebral cortex: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
-0.07
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G3 as an antibody target. Whether an autoantibody or antibody against PLA2G3 could matter depends on whether native PLA2G3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G3 is annotated at the cell surface, where native PLA2G3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLA2G3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLA2G3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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