Seroatlas · Human Serome Atlas

PLA2G2F

Group IIF secretory phospholipase A2

Also known as: PA2GF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZM2
Gene: PLA2G2F
Ensembl: ENSG00000158786
Chromosome: 1
Canonical length: 168 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables calcium-dependent phospholipase A2 activity. Involved in glycerophospholipid metabolic process. Predicted to be located in cytosol and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>Q9BZM2|PLA2G2F
     1  MKKFFTVAIL AGSVLSTAHG SLLNLKAMVE AVTGRSAILS FVGYGCYCGL GGRGQPKDEV
    61  DWCCHAHDCC YQELFDQGCH PYVDHYDHTI ENNTEIVCSD LNKTECDKQT CMCDKNMVLC
   121  LMNQTYREEY RGFLNVYCQG PTPNCSIYEP PPEEVTCSHQ SPAPPAPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G2F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skin: 14 nTPM
urinary bladder: 9.8 nTPM
tonsil: 7.5 nTPM
thymus: 0.7 nTPM
gallbladder: 0.4 nTPM
vagina: 0.3 nTPM

Single-cell type

urothelial cells: 39 nCPM
prostatic hillock cells: 8.2 nCPM
papillary tip epithelial cells: 7.1 nCPM
foveolar cells: 5.1 nCPM
prostatic club cells: 3.8 nCPM
suprabasal keratinocytes: 1.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.2 nTPM
amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G2F as an antibody target. Whether an autoantibody or antibody against PLA2G2F could matter depends on whether native PLA2G2F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G2F is annotated at the cell surface, where native PLA2G2F is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLA2G2F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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