Seroatlas · Human Serome Atlas

PLA2G2D

Group IID secretory phospholipase A2

Also known as: PA2GD_HUMAN, sPLA2S

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNK4
Gene: PLA2G2D
Ensembl: ENSG00000117215
Chromosome: 1
Canonical length: 145 aa
Protein class: Enzymes, Metabolic proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q9UNK4|PLA2G2D
     1  MELALLCGLV VMAGVIPIQG GILNLNKMVK QVTGKMPILS YWPYGCHCGL GGRGQPKDAT
    61  DWCCQTHDCC YDHLKTQGCS IYKDYYRYNF SQGNIHCSDK GSWCEQQLCA CDKEVAFCLK
   121  RNLDTYQKRL RFYWRPHCRG QTPGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G2D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

lymph node: 100 nTPM
tonsil: 55 nTPM
appendix: 15 nTPM
spleen: 10 nTPM
urinary bladder: 4.2 nTPM
small intestine: 4.1 nTPM

Single-cell type

plasma cells: 13 nCPM
kupffer cells: 6.1 nCPM
macrophages: 3.1 nCPM
retinal horizontal cells: 2 nCPM
pancreatic islet cells: 0.6 nCPM
neuroendocrine cells: 0.5 nCPM

Immune cell

memory B-cell: 3.7 nTPM
naive B-cell: 3.7 nTPM
plasmacytoid DC: 2 nTPM
basophil: 0.5 nTPM
classical monocyte: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

cerebellum: 1.6 nTPM
cerebral cortex: 1.6 nTPM
white matter: 1.5 nTPM
hippocampal formation: 1.4 nTPM
pons: 1.4 nTPM
amygdala: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

arachidonate secretion
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
inflammatory response
lipid catabolic process
negative regulation of T cell proliferation
phosphatidylcholine metabolic process
phosphatidylethanolamine metabolic process
phosphatidylglycerol metabolic process
phospholipid metabolic process
regulation of acute inflammatory response to antigenic stimulus

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G2D as an antibody target. Whether an autoantibody or antibody against PLA2G2D could matter depends on whether native PLA2G2D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G2D is annotated as secreted, so native PLA2G2D circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLA2G2D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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