Seroatlas · Human Serome Atlas

PLA2G2C

Putative inactive group IIC secretory phospholipase A2

Also known as: PA2GC_HUMAN, UBXN10-AS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5R387
Gene: PLA2G2C
Ensembl: ENSG00000187980
Chromosome: 1
Canonical length: 149 aa
Protein class: Predicted secreted proteins, RAS pathway related proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in phosphatidylcholine metabolic process and phosphatidylglycerol metabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q5R387|PLA2G2C
     1  MKVIAILTLL LFCSPTHSSF WQFQRRVKHI TGRSAFFSYY GYGCYCGLGD KGIPVDDTDR
    61  HSPSSPSPYE KLKEFSCQPV LNSYQFHIVN GAVVCGCTLG PGASCHCRLK ACECDKQSVH
   121  CFKESLPTYE KNFKQFSSQP RCGRHKPWC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 3.2 nTPM

Expression across tissuesHPA

Tissue

colon: 3.2 nTPM
esophagus: 0.7 nTPM
small intestine: 0.5 nTPM
stomach: 0.5 nTPM
prostate: 0.4 nTPM
testis: 0.4 nTPM

Single-cell type

epididymal principal cells: 71 nCPM
late spermatids: 43 nCPM
smooth muscle cells: 31 nCPM
late primary spermatocytes: 23 nCPM
early spermatids: 18 nCPM
mast cells: 17 nCPM

Immune cell

MAIT T-cell: 0.8 nTPM
myeloid DC: 0.5 nTPM
basophil: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM
gdT-cell: 0.3 nTPM

Brain region

cerebellum: 3.5 nTPM
cerebral cortex: 3 nTPM
hippocampal formation: 2.9 nTPM
midbrain: 2.9 nTPM
basal ganglia: 2.8 nTPM
hypothalamus: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.04
gnomAD missense Z: -0.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G2C as an antibody target. Whether an autoantibody or antibody against PLA2G2C could matter depends on whether native PLA2G2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G2C is annotated as secreted, so native PLA2G2C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLA2G2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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