Seroatlas · Human Serome Atlas

PLA2G2A

Phospholipase A2, membrane associated

Also known as: PA2GA_HUMAN, PLA2B, PLA2L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14555
Gene
PLA2G2A
Ensembl
ENSG00000188257
Chromosome
1
Canonical length
144 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>P14555|PLA2G2A
     1  MKTLLLLAVI MIFGLLQAHG NLVNFHRMIK LTTGKEAALS YGFYGCHCGV GGRGSPKDAT
    61  DRCCVTHDCC YKRLEKRGCG TKFLSYKFSN SGSRITCAKQ DSCRSQLCEC DKAAATCFAR
   121  NKTTYNKKYQ YYSNKHCRGS TPRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
2,383 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 2,383 nTPM
  • liver: 1,824 nTPM
  • blood vessel: 1,581 nTPM
  • small intestine: 1,417 nTPM
  • rectum: 1,136 nTPM
  • colon: 1,023 nTPM

Single-cell type

  • paneth cells: 12,515 nCPM
  • fibroblasts: 2,413 nCPM
  • decidual stromal cells: 1,513 nCPM
  • prostatic glandular cells: 1,378 nCPM
  • ocular epithelial cells: 982 nCPM
  • enteric transient amplifying cells: 560 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 6 nTPM
  • thalamus: 2.6 nTPM
  • midbrain: 1.6 nTPM
  • medulla oblongata: 1.3 nTPM
  • pons: 0.5 nTPM
  • hypothalamus: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLA2G2A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 32 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0.1
gnomAD missense Z
0.68
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G2A as an antibody target. Whether an autoantibody or antibody against PLA2G2A could matter depends on whether native PLA2G2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G2A is annotated at the cell surface, where native PLA2G2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLA2G2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLA2G2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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