Seroatlas · Human Serome Atlas

PLA2G15

Lysosomal phospholipase A and acyltransferase

Also known as: GXVPLA2, LLPL, LYPLA3, PAG15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCC3
Gene
PLA2G15
Ensembl
ENSG00000103066
Chromosome
16
Canonical length
412 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q8NCC3|PLA2G15
     1  MGLHLRPYRV GLLPDGLLFL LLLLMLLADP ALPAGRHPPV VLVPGDLGNQ LEAKLDKPTV
    61  VHYLCSKKTE SYFTIWLNLE LLLPVIIDCW IDNIRLVYNK TSRATQFPDG VDVRVPGFGK
   121  TFSLEFLDPS KSSVGSYFHT MVESLVGWGY TRGEDVRGAP YDWRRAPNEN GPYFLALREM
   181  IEEMYQLYGG PVVLVAHSMG NMYTLYFLQR QPQAWKDKYI RAFVSLGAPW GGVAKTLRVL
   241  ASGDNNRIPV IGPLKIREQQ RSAVSTSWLL PYNYTWSPEK VFVQTPTINY TLRDYRKFFQ
   301  DIGFEDGWLM RQDTEGLVEA TMPPGVQLHC LYGTGVPTPD SFYYESFPDR DPKICFGDGD
   361  GTVNLKSALQ CQAWQSRQEH QVLLQELPGS EHIEMLANAT TLAYLKRVLL GP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 56 nTPM
  • heart muscle: 33 nTPM
  • kidney: 33 nTPM
  • placenta: 26 nTPM
  • tongue: 21 nTPM
  • cerebellum: 21 nTPM

Single-cell type

  • hofbauer cells: 205 nCPM
  • kupffer cells: 85 nCPM
  • microglia: 64 nCPM
  • syncytiotrophoblasts: 58 nCPM
  • macrophages: 48 nCPM
  • proximal tubule cells: 37 nCPM

Immune cell

  • non-classical monocyte: 33 nTPM
  • intermediate monocyte: 28 nTPM
  • classical monocyte: 24 nTPM
  • basophil: 20 nTPM
  • eosinophil: 16 nTPM
  • total PBMC: 15 nTPM

Brain region

  • thalamus: 22 nTPM
  • white matter: 21 nTPM
  • pons: 18 nTPM
  • midbrain: 17 nTPM
  • hypothalamus: 17 nTPM
  • cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.38
gnomAD missense Z
0.75
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G15 as an antibody target. Whether an autoantibody or antibody against PLA2G15 could matter depends on whether native PLA2G15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G15 is annotated as secreted, so native PLA2G15 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLA2G15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLA2G15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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