Seroatlas · Human Serome Atlas

PLA2G12B

Group XIIB secretory phospholipase A2-like protein

Also known as: PG12B_HUMAN, PLA2G13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BX93
Gene: PLA2G12B
Ensembl: ENSG00000138308
Chromosome: 10
Canonical length: 195 aa
Protein class: Plasma proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q9BX93|PLA2G12B
     1  MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF DSFLELLGGK
    61  NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES MDLGIPAMTK CCNQLDVCYD
   121  TCGANKYRCD AKFRWCLHSI CSDLKRSLGF VSKVEAACDS LVDTVFNTVW TLGCRPFMNS
   181  QRAACICAEE EKEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

liver: 66 nTPM
small intestine: 31 nTPM
duodenum: 25 nTPM
kidney: 13 nTPM
heart muscle: 3.3 nTPM
colon: 1.9 nTPM

Single-cell type

enterocytes: 121 nCPM
hepatocytes: 74 nCPM
proximal tubule cells: 23 nCPM
early spermatids: 19 nCPM
enteric transient amplifying cells: 13 nCPM
enteric stem cells: 8.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.9 nTPM
cerebral cortex: 0.7 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G12B as an antibody target. Whether an autoantibody or antibody against PLA2G12B could matter depends on whether native PLA2G12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G12B is annotated as secreted, so native PLA2G12B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLA2G12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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