PKIB
cAMP-dependent protein kinase inhibitor beta
Also known as: IPKB_HUMAN, PRKACN2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9C010
- Gene
- PKIB
- Ensembl
- ENSG00000135549
- Chromosome
- 6
- Canonical length
- 78 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Canonical amino-acid sequenceUniProt
78 residues, UniProt reviewed canonical sequence.
>Q9C010|PKIB
1 MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE ALSVKEDAKE
61 KDEKTTQDQL EKPQNEEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PKIB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 248 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 248 nTPM
- colon: 87 nTPM
- parathyroid gland: 60 nTPM
- rectum: 59 nTPM
- placenta: 57 nTPM
- retina: 52 nTPM
Single-cell type
- syncytiotrophoblasts: 1,108 nCPM
- colonocytes: 901 nCPM
- cytotrophoblasts: 811 nCPM
- migrating cytotrophoblasts: 627 nCPM
- extravillous trophoblasts: 555 nCPM
- late spermatids: 438 nCPM
Immune cell
- myeloid DC: 35 nTPM
- intermediate monocyte: 3.4 nTPM
- NK-cell: 2.8 nTPM
- MAIT T-cell: 0.8 nTPM
- total PBMC: 0.7 nTPM
- classical monocyte: 0.6 nTPM
Brain region
- cerebellum: 146 nTPM
- pons: 27 nTPM
- medulla oblongata: 15 nTPM
- midbrain: 13 nTPM
- hypothalamus: 12 nTPM
- thalamus: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.71
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 0.43
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PKIB as an antibody target. Whether an autoantibody or antibody against PKIB could matter depends on whether native PKIB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PKIB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PKIB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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