Seroatlas · Human Serome Atlas

PKDCC

Extracellular tyrosine-protein kinase PKDCC

Also known as: PKDCC_HUMAN, SgK493, Vlk

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q504Y2
Gene
PKDCC
Ensembl
ENSG00000162878
Chromosome
2
Canonical length
493 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

Enables non-membrane spanning protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation and skeletal system development. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q504Y2|PKDCC
     1  MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR GGRGELARQI
    61  RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP RPPWARPLSD GAPGWPPAPG
   121  PGSPGPGPRL GCAALRNVSG AQYMGSGYTK AVYRVRLPGG AAVALKAVDF SGHDLGSCVR
   181  EFGVRRGCYR LAAHKLLKEM VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE
   241  MIQLLQTSWE DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR
   301  VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY LLPHSAPPSL
   361  RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN STASSSTEYQ CIPDSTIPQE
   421  DYRCWPSYHH GSCLLSVFNL AEAVDVCESH AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV
   481  PDPNKTTYVK ASG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PKDCC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 85 nTPM
  • ovary: 50 nTPM
  • heart muscle: 37 nTPM
  • cervix: 34 nTPM
  • blood vessel: 33 nTPM
  • urinary bladder: 31 nTPM

Single-cell type

  • leydig cells: 208 nCPM
  • peritubular myoid cells: 176 nCPM
  • thymic myoid cells: 143 nCPM
  • alveolar cells type 1: 120 nCPM
  • rod photoreceptor cells: 97 nCPM
  • smooth muscle cells: 88 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 14 nTPM
  • cerebral cortex: 12 nTPM
  • white matter: 11 nTPM
  • hippocampal formation: 8.4 nTPM
  • basal ganglia: 8.1 nTPM
  • amygdala: 7.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PKDCC.

Disease | AllUniProt

Conditions PKDCC is implicated in, by any mechanism.

  • Rhizomelic limb shortening with dysmorphic features (RLSDF) MIM:618821

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 280 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
-0.29
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PKDCC as an antibody target. Whether an autoantibody or antibody against PKDCC could matter depends on whether native PKDCC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PKDCC is annotated as secreted, so native PKDCC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PKDCC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PKDCC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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