Seroatlas · Human Serome Atlas

PKD2L2

Polycystin-2-like protein 2

Also known as: PK2L2_HUMAN, TRPP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZM6
Gene: PKD2L2
Ensembl: ENSG00000078795
Chromosome: 5
Canonical length: 624 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

624 residues, UniProt reviewed canonical sequence.

>Q9NZM6|PKD2L2
     1  MAEASRWHRG GASKHKLHYR KEVEITTTLQ ELLLYFIFLI NLCILTFGMV NPHMYYLNKV
    61  MSSLFLDTSV PGEERTNFKS IRSITDFWKF MEGPLLEGLY WDSWYNNQQL YNLKNSSRIY
   121  YENILLGVPR VRQLKVRNNT CKVYSSFQSL MSECYGKYTS ANEDLSNFGL QINTEWRYST
   181  SNTNSPWHWG FLGVYRNGGY IFTLSKSKSE TKNKFIDLRL NSWITRGTRV IFIDFSLYNA
   241  NVNLFCIIRL VAEFPATGGI LTSWQFYSVK LLRYVSYYDY FIASCEITFC IFLFVFTTQE
   301  VKKIKEFKSA YFKSIWNWLE LLLLLLCFVA VSFNTYYNVQ IFLLLGQLLK STEKYSDFYF
   361  LACWHIYYNN IIAITIFFAW IKIFKFISFN KTMSQLSSTL SRCVKDIVGF AIMFFIIFFA
   421  YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV LGDFNFAGIQ QANPILGPIY FITFIFFVFF
   481  VLLNMFLAII NDTYSEVKAD YSIGRRLDFE LGKMIKQSYK NVLEKFRLKK AQKDEDKKTK
   541  GSGDLAEQAR REGFDENEIQ NAEQMKKWKE RLEKKYYSME IQDDYQPVTQ EEFRELFLYA
   601  VELEKELHYI NLKLNQVVRK VSAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PKD2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

testis: 7.6 nTPM
skeletal muscle: 2.1 nTPM
bone marrow: 1.4 nTPM
heart muscle: 1 nTPM
retina: 1 nTPM
adrenal gland: 0.9 nTPM

Single-cell type

cardiomyocytes: 620 nCPM
late primary spermatocytes: 185 nCPM
epicardial cells: 157 nCPM
myonuclei: 89 nCPM
early spermatids: 70 nCPM
thymocytes: 64 nCPM

Immune cell

basophil: 5.2 nTPM
neutrophil: 3.8 nTPM
plasmacytoid DC: 1.9 nTPM
eosinophil: 1.8 nTPM
naive B-cell: 1.8 nTPM
memory B-cell: 1.4 nTPM

Brain region

cerebellum: 14 nTPM
white matter: 14 nTPM
basal ganglia: 11 nTPM
hypothalamus: 10 nTPM
cerebral cortex: 10 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of mechanical stimulus

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PKD2L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PKD2L2 as an antibody target. Whether an autoantibody or antibody against PKD2L2 could matter depends on whether native PKD2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PKD2L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PKD2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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