PIPOX
Peroxisomal sarcosine oxidase
Also known as: LPIPOX, SOX_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P0Z9
- Gene
- PIPOX
- Ensembl
- ENSG00000179761
- Chromosome
- 17
- Canonical length
- 390 aa
- Protein class
- Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
OverviewNCBI Gene
Enables L-pipecolate oxidase activity and sarcosine oxidase activity. Involved in L-lysine catabolic process to acetyl-CoA via L-pipecolate. Located in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
390 residues, UniProt reviewed canonical sequence.
>Q9P0Z9|PIPOX
1 MAAQKDLWDA IVIGAGIQGC FTAYHLAKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL
61 EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL
121 SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP
181 GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS
241 QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS
301 FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI
361 LYELSMKLTP SYDLAPFRIS RFPSLGKAHLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PIPOX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.23
- Highest tissue expression
- 474 nTPM
Expression across tissuesHPA
Tissue
- liver: 474 nTPM
- kidney: 136 nTPM
- epididymis: 23 nTPM
- midbrain: 16 nTPM
- duodenum: 13 nTPM
- basal ganglia: 12 nTPM
Single-cell type
- late spermatids: 864 nCPM
- hepatocytes: 271 nCPM
- early spermatids: 190 nCPM
- bergmann glia: 57 nCPM
- late primary spermatocytes: 56 nCPM
- epididymal principal cells: 44 nCPM
Immune cell
- myeloid DC: 1.8 nTPM
- neutrophil: 1 nTPM
- basophil: 0.9 nTPM
- naive CD8 T-cell: 0.7 nTPM
- memory CD8 T-cell: 0.4 nTPM
- T-reg: 0.4 nTPM
Brain region
- cerebellum: 18 nTPM
- basal ganglia: 18 nTPM
- midbrain: 16 nTPM
- thalamus: 16 nTPM
- hypothalamus: 14 nTPM
- medulla oblongata: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.26
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.24
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- lysine catabolic process
- L-lysine catabolic process to acetyl-CoA via L-pipecolate
Molecular functions
- flavin adenine dinucleotide binding
- L-pipecolate oxidase activity
- sarcosine oxidase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PIPOX as an antibody target. Whether an autoantibody or antibody against PIPOX could matter depends on whether native PIPOX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PIPOX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PIPOX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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