Seroatlas · Human Serome Atlas

PINLYP

phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

Also known as: PINLY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NC86
Gene
PINLYP
Ensembl
ENSG00000234465
Chromosome
19
Canonical length
204 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Vesicles,Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Centrosome,Basal body
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to enable phospholipase inhibitor activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>A6NC86|PINLYP
     1  MRLSRRPETF LLAFVLLCTL LGLGCPLHCE ICTAAGSRCH GQMKTCSSDK DTCVLLVGKA
    61  TSKGKELVHT YKGCIRSQDC YSGVISTTMG PKDHMVTSSF CCQSDGCNSA FLSVPLTNLT
   121  ENGLMCPACT ASFRDKCMGP MTHCTGKENH CVSLSGHVQA GIFKPRFAMR GCATESMCFT
   181  KPGAEVPTGT NVLFLHHIEC THSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PINLYP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 26 nTPM
  • ovary: 22 nTPM
  • basal ganglia: 18 nTPM
  • cervix: 17 nTPM
  • fallopian tube: 16 nTPM
  • amygdala: 16 nTPM

Single-cell type

  • decidual stromal cells: 33 nCPM
  • ovarian stromal cells: 27 nCPM
  • leydig cells: 27 nCPM
  • hepatic stellate cells: 26 nCPM
  • esophageal basal cells: 25 nCPM
  • peritubular myoid cells: 23 nCPM

Immune cell

  • plasmacytoid DC: 21 nTPM
  • basophil: 11 nTPM
  • naive B-cell: 4.8 nTPM
  • MAIT T-cell: 3.6 nTPM
  • naive CD8 T-cell: 3.6 nTPM
  • gdT-cell: 3 nTPM

Brain region

  • cerebellum: 11 nTPM
  • hypothalamus: 9.7 nTPM
  • medulla oblongata: 9.4 nTPM
  • midbrain: 9 nTPM
  • basal ganglia: 8.1 nTPM
  • thalamus: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0.66
gnomAD missense Z
0.57
DepMap mean gene effect
0.05
DepMap dependency class
none

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PINLYP as an antibody target. Whether an autoantibody or antibody against PINLYP could matter depends on whether native PINLYP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PINLYP is annotated as secreted, so native PINLYP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PINLYP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PINLYP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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