Seroatlas · Human Serome Atlas

PIM2

Serine/threonine-protein kinase pim-2

Also known as: PIM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1W9
Gene: PIM2
Ensembl: ENSG00000102096
Chromosome: X
Canonical length: 311 aa
Protein class: Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q9P1W9|PIM2
     1  MLTKPLQGPP APPGTPTPPP GGKDREAFEA EYRLGPLLGK GGFGTVFAGH RLTDRLQVAI
    61  KVIPRNRVLG WSPLSDSVTC PLEVALLWKV GAGGGHPGVI RLLDWFETQE GFMLVLERPL
   121  PAQDLFDYIT EKGPLGEGPS RCFFGQVVAA IQHCHSRGVV HRDIKDENIL IDLRRGCAKL
   181  IDFGSGALLH DEPYTDFDGT RVYSPPEWIS RHQYHALPAT VWSLGILLYD MVCGDIPFER
   241  DQEILEAELH FPAHVSPDCC ALIRRCLAPK PSSRPSLEEI LLDPWMQTPA EDVPLNPSKG
   301  GPAPLAWSLL P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 153 nTPM

Expression across tissuesHPA

Tissue

spleen: 153 nTPM
lymph node: 107 nTPM
tonsil: 98 nTPM
bone marrow: 97 nTPM
duodenum: 82 nTPM
appendix: 81 nTPM

Single-cell type

plasma cells: 421 nCPM
mast cells: 82 nCPM
innate lymphoid cells: 78 nCPM
neutrophils: 69 nCPM
t-cells: 58 nCPM
cdc: 53 nCPM

Immune cell

T-reg: 333 nTPM
basophil: 281 nTPM
neutrophil: 196 nTPM
naive CD4 T-cell: 173 nTPM
memory CD4 T-cell: 166 nTPM
memory B-cell: 125 nTPM

Brain region

hippocampal formation: 30 nTPM
hypothalamus: 26 nTPM
cerebral cortex: 23 nTPM
pons: 23 nTPM
choroid plexus: 21 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.95
gnomAD missense Z: 1.34
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIM2 as an antibody target. Whether an autoantibody or antibody against PIM2 could matter depends on whether native PIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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