Seroatlas · Human Serome Atlas

PILRB

Paired immunoglobulin-like type 2 receptor beta

Also known as: FDFACT1, FDFACT2, PILRB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKJ0
Gene: PILRB
Ensembl: ENSG00000121716
Chromosome: 7
Canonical length: 227 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q9UKJ0|PILRB
     1  MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE
    61  LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ
   121  SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE
   181  SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PILRB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 264 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 264 nTPM
cerebellum: 240 nTPM
testis: 220 nTPM
liver: 204 nTPM
kidney: 182 nTPM
thyroid gland: 177 nTPM

Single-cell type

proximal tubule cells: 86 nCPM
choroid plexus epithelial cells: 80 nCPM
distal convoluted tubule cells: 71 nCPM
loop of henle epithelial cells: 68 nCPM
renal connecting tubule cells: 59 nCPM
astrocytes: 58 nCPM

Immune cell

eosinophil: 252 nTPM
neutrophil: 142 nTPM
non-classical monocyte: 76 nTPM
intermediate monocyte: 59 nTPM
classical monocyte: 36 nTPM
total PBMC: 26 nTPM

Brain region

cerebellum: 129 nTPM
choroid plexus: 100 nTPM
cerebral cortex: 76 nTPM
white matter: 70 nTPM
hippocampal formation: 67 nTPM
thalamus: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

MHC class I protein binding

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PILRB as an antibody target. Whether an autoantibody or antibody against PILRB could matter depends on whether native PILRB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PILRB is annotated at the cell surface, where native PILRB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PILRB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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