Seroatlas · Human Serome Atlas

PILRA

Paired immunoglobulin-like type 2 receptor alpha

Also known as: FDF03, PILRA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKJ1
Gene: PILRA
Ensembl: ENSG00000085514
Chromosome: 7
Canonical length: 303 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q9UKJ1|PILRA
     1  MGRPLLLPLL PLLLPPAFLQ PSGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE
    61  LATAPDVRIS WRRGHFHRQS FYSTRPPSIH KDYVNRLFLN WTEGQKSGFL RISNLQKQDQ
   121  SVYFCRVELD TRSSGRQQWQ SIEGTKLSIT QAVTTTTQRP SSMTTTWRLS STTTTTGLRV
   181  TQGKRRSDSW HISLETAVGV AVAVTVLGIM ILGLICLLRW RRRKGQQRTK ATTPAREPFQ
   241  NTEEPYENIR NEGQNTDPKL NPKDDGIVYA SLALSSSTSP RAPPSHRPLK SPQNETLYSV
   301  LKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PILRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

appendix: 36 nTPM
spleen: 30 nTPM
lung: 29 nTPM
bone marrow: 24 nTPM
cerebellum: 24 nTPM
urinary bladder: 17 nTPM

Single-cell type

neutrophils: 1,383 nCPM
monocytes: 226 nCPM
microglia: 148 nCPM
endometrial glandular cells: 119 nCPM
decidual stromal cells: 100 nCPM
macrophages: 98 nCPM

Immune cell

neutrophil: 1,664 nTPM
non-classical monocyte: 1,151 nTPM
intermediate monocyte: 863 nTPM
classical monocyte: 585 nTPM
total PBMC: 354 nTPM
basophil: 318 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 19 nTPM
cerebellum: 18 nTPM
pons: 15 nTPM
cerebral cortex: 14 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

MHC class I protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PILRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PTPN6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PILRA as an antibody target. Whether an autoantibody or antibody against PILRA could matter depends on whether native PILRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PILRA is annotated at the cell surface, where native PILRA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PILRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...