Seroatlas · Human Serome Atlas

PIK3IP1

Phosphoinositide-3-kinase-interacting protein 1

Also known as: HGFL, MGC17330, P3IP1_HUMAN, TrIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FE7
Gene: PIK3IP1
Ensembl: ENSG00000100100
Chromosome: 22
Canonical length: 263 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables phosphatidylinositol 3-kinase inhibitor activity. Involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q96FE7|PIK3IP1
     1  MLLAWVQAFL VSNMLLAEAY GSGGCFWDNG HLYREDQTSP APGLRCLNWL DAQSGLASAP
    61  VSGAGNHSYC RNPDEDPRGP WCYVSGEAGV PEKRPCEDLR CPETTSQALP AFTTEIQEAS
   121  EGPGADEVQV FAPANALPAR SEAAAVQPVI GISQRVRMNS KEKKDLGTLG YVLGITMMVI
   181  IIAIGAGIIL GYSYKRGKDL KEQHDQKVCE REMQRITLPL SAFTNPTCEI VDEKTVVVHT
   241  SQTPVDPQEG TTPLMGQAGT PGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIK3IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

lymph node: 103 nTPM
tonsil: 75 nTPM
spleen: 70 nTPM
thymus: 64 nTPM
small intestine: 60 nTPM
skin: 57 nTPM

Single-cell type

t-cells: 230 nCPM
innate lymphoid cells: 224 nCPM
nk-cells: 166 nCPM
b-cells: 136 nCPM
mast cells: 132 nCPM
platelets: 123 nCPM

Immune cell

naive CD4 T-cell: 501 nTPM
naive CD8 T-cell: 319 nTPM
T-reg: 258 nTPM
total PBMC: 215 nTPM
memory CD4 T-cell: 208 nTPM
memory CD8 T-cell: 114 nTPM

Brain region

medulla oblongata: 87 nTPM
white matter: 81 nTPM
pons: 72 nTPM
spinal cord: 66 nTPM
basal ganglia: 63 nTPM
thalamus: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.02
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIK3IP1 as an antibody target. Whether an autoantibody or antibody against PIK3IP1 could matter depends on whether native PIK3IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIK3IP1 is annotated at the cell surface, where native PIK3IP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PIK3IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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