Seroatlas · Human Serome Atlas

PIH1D2

PIH1 domain-containing protein 2

Also known as: DNAAF15, PIHD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWB5
Gene: PIH1D2
Ensembl: ENSG00000150773
Chromosome: 11
Canonical length: 315 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables small GTPase binding activity. Predicted to be involved in box C/D snoRNP assembly and rRNA processing. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8WWB5|PIH1D2
     1  METSSKGLLT QVTQFWNLLD DLAQSDPEGY EKFIQQQLKE GKQLCAAPEP QLCLQTRILK
    61  PKEKILFINL CQWTRIPAPQ STTHPVPLTV GKPEDTTEIS DAYTVIDVAY NPDVLHAAEK
   121  DQVKKNQLIQ MAMKCIEEKF QFTLSHSYHI TKFRIKGSIQ RMKQNLMGIQ TDSIDLREKM
   181  RRELTLGQIR SSTMSNPDHF PQLLLPKDQV SGKAVCLIEE ISSTEIQVEM KMPAYELKIV
   241  HDHSEKPLKI ELKVELPGIN SVSLCDLSVS EDDLLIEVSE KYRLHLNLPK LIDTEMTTAK
   301  FIKEKSTLII TMPLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIH1D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

testis: 62 nTPM
fallopian tube: 14 nTPM
retina: 11 nTPM
choroid plexus: 9 nTPM
thyroid gland: 5 nTPM
epididymis: 4.5 nTPM

Single-cell type

late primary spermatocytes: 674 nCPM
early spermatids: 371 nCPM
late spermatids: 179 nCPM
respiratory ciliated cells: 177 nCPM
fallopian tube ciliated cells: 154 nCPM
ependymal cells: 102 nCPM

Immune cell

eosinophil: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 20 nTPM
midbrain: 8.9 nTPM
medulla oblongata: 7.8 nTPM
spinal cord: 6.6 nTPM
white matter: 4.3 nTPM
pons: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

small GTPase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIH1D2 as an antibody target. Whether an autoantibody or antibody against PIH1D2 could matter depends on whether native PIH1D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIH1D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIH1D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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