Seroatlas · Human Serome Atlas

PIGT

GPI-anchor transamidase component PIGT

Also known as: PIGT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969N2
Gene
PIGT
Ensembl
ENSG00000124155
Chromosome
20
Canonical length
578 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q969N2|PIGT
     1  MAAAMPLALL VLLLLGPGGW CLAEPPRDSL REELVITPLP SGDVAATFQF RTRWDSELQR
    61  EGVSHYRLFP KALGQLISKY SLRELHLSFT QGFWRTRYWG PPFLQAPSGA ELWVWFQDTV
   121  TDVDKSWKEL SNVLSGIFCA SLNFIDSTNT VTPTASFKPL GLANDTDHYF LRYAVLPREV
   181  VCTENLTPWK KLLPCSSKAG LSVLLKADRL FHTSYHSQAV HIRPVCRNAR CTSISWELRQ
   241  TLSVVFDAFI TGQGKKDWSL FRMFSRTLTE PCPLASESRV YVDITTYNQD NETLEVHPPP
   301  TTTYQDVILG TRKTYAIYDL LDTAMINNSR NLNIQLKWKR PPENEAPPVP FLHAQRYVSG
   361  YGLQKGELST LLYNTHPYRA FPVLLLDTVP WYLRLYVHTL TITSKGKENK PSYIHYQPAQ
   421  DRLQPHLLEM LIQLPANSVT KVSIQFERAL LKWTEYTPDP NHGFYVSPSV LSALVPSMVA
   481  AKPVDWEESP LFNSLFPVSD GSNYFVRLYT EPLLVNLPTP DFSMPYNVIC LTCTVVAVCY
   541  GSFYNLLTRT FHIEEPRTGG LAKRLANLIR RARGVPPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIGT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 112 nTPM
  • heart muscle: 105 nTPM
  • parathyroid gland: 98 nTPM
  • epididymis: 85 nTPM
  • rectum: 72 nTPM
  • colon: 70 nTPM

Single-cell type

  • decidual stromal cells: 203 nCPM
  • goblet cells: 142 nCPM
  • late spermatids: 139 nCPM
  • differentiating spermatogonia: 124 nCPM
  • epididymal principal cells: 122 nCPM
  • colonocytes: 108 nCPM

Immune cell

  • myeloid DC: 91 nTPM
  • intermediate monocyte: 82 nTPM
  • total PBMC: 81 nTPM
  • non-classical monocyte: 78 nTPM
  • classical monocyte: 77 nTPM
  • plasmacytoid DC: 70 nTPM

Brain region

  • white matter: 62 nTPM
  • choroid plexus: 57 nTPM
  • medulla oblongata: 49 nTPM
  • cerebellum: 49 nTPM
  • thalamus: 44 nTPM
  • pons: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIGT.

Disease | AllUniProt

Conditions PIGT is implicated in, by any mechanism.

  • Multiple congenital anomalies-hypotonia-seizures syndrome 3 (MCAHS3) MIM:615398
  • Paroxysmal nocturnal hemoglobinuria 2 (PNH2) MIM:615399

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 396 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • GPI transamidase component PIG-T
  • Gpi16 subunit, GPI transamidase component

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIGT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIGT as an antibody target. Whether an autoantibody or antibody against PIGT could matter depends on whether native PIGT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIGT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIGT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PIGT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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