PIGBOS1
Protein PIGBOS1
Also known as: PIOS1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0B4J2F0
- Gene
- PIGBOS1
- Ensembl
- ENSG00000225973
- Chromosome
- 15
- Canonical length
- 54 aa
- Protein class
- Predicted intracellular proteins
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Involved in regulation of endoplasmic reticulum unfolded protein response. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
54 residues, UniProt reviewed canonical sequence.
>A0A0B4J2F0|PIGBOS1
1 MFRRLTFAQL LFATVLGIAG GVYIFQPVFE QYAKDQKELK EKMQLVQESE EKKSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PIGBOS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 16 nTPM
- spinal cord: 15 nTPM
- spleen: 14 nTPM
- thyroid gland: 14 nTPM
- stomach: 13 nTPM
- breast: 13 nTPM
Single-cell type
- tuft cells: 23 nCPM
- hepatocytes: 11 nCPM
- monocyte progenitors: 8.3 nCPM
- hematopoietic stem cells: 7.8 nCPM
- neutrophils: 7.7 nCPM
- enterocytes: 6.9 nCPM
Immune cell
- eosinophil: 58 nTPM
- basophil: 49 nTPM
- non-classical monocyte: 47 nTPM
- neutrophil: 44 nTPM
- plasmacytoid DC: 43 nTPM
- classical monocyte: 42 nTPM
Brain region
- white matter: 15 nTPM
- medulla oblongata: 13 nTPM
- choroid plexus: 13 nTPM
- cerebral cortex: 12 nTPM
- pons: 12 nTPM
- hypothalamus: 12 nTPM
OntologyGO
Biological processes
- response to unfolded protein
- regulation of endoplasmic reticulum unfolded protein response
Cellular components
Protein domainsUniProt · Pfam · InterPro
- PIGBOS1-like
- PIGBOS1-like
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PIGBOS1 as an antibody target. Whether an autoantibody or antibody against PIGBOS1 could matter depends on whether native PIGBOS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PIGBOS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PIGBOS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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