Seroatlas · Human Serome Atlas

PIANP

PILR alpha-associated neural protein

Also known as: C12orf53, DKFZp547D2210, PANP, PIANP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYJ0
Gene: PIANP
Ensembl: ENSG00000139200
Chromosome: 12
Canonical length: 282 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q8IYJ0|PIANP
     1  MESRMWPALL LSHLLPLWPL LLLPLPPPAQ GSSSSPRTPP APARPPCARG GPSAPRHVCV
    61  WERAPPPSRS PRVPRSRRQV LPGTAPPATP SGFEEGPPSS QYPWAIVWGP TVSREDGGDP
   121  NSANPGFLDY GFAAPHGLAT PHPNSDSMRG DGDGLILGEA PATLRPFLFG GRGEGVDPQL
   181  YVTITISIII VLVATGIIFK FCWDRSQKRR RPSGQQGALR QEESQQPLTD LSPAGVTVLG
   241  AFGDSPTPTP DHEEPRGGPR PGMPHPKGAP AFQLNRIPLV NL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIANP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 143 nTPM
cerebral cortex: 103 nTPM
hypothalamus: 95 nTPM
amygdala: 89 nTPM
cerebellum: 80 nTPM
hippocampal formation: 76 nTPM

Single-cell type

other brain neurons: 47 nCPM
brain inhibitory neurons: 43 nCPM
adrenal medulla cells: 32 nCPM
brain excitatory neurons: 30 nCPM
oligodendrocyte progenitor cells: 27 nCPM
retinal amacrine cells: 18 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 198 nTPM
amygdala: 193 nTPM
hypothalamus: 176 nTPM
basal ganglia: 168 nTPM
white matter: 162 nTPM
hippocampal formation: 160 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.38
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein domain specific binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

AJAP1/PANP, C-terminal
AJAP1/PANP C-terminus
PILR alpha-associated neural protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIANP as an antibody target. Whether an autoantibody or antibody against PIANP could matter depends on whether native PIANP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIANP is annotated at the cell surface, where native PIANP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PIANP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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