Seroatlas · Human Serome Atlas

PI4KAP2

Putative phosphatidylinositol 4-kinase alpha-like protein P2

Also known as: PI4P2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4QPH2
Gene: PI4KAP2
Canonical length: 592 aa

OverviewNCBI Gene

No narrative summary is available for PI4KAP2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>A4QPH2|PI4KAP2
     1  MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE IAKYCSSDQV
    61  EIFSSLLQRS MSLNIGRAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK
   121  IYSTAFDYFS CPPKFPTQGE KRLREDISIM IKFWTAMFSD KKYLTASQLV PPADIGDLLE
   181  QLVEENTGSL SGPAKDFYQR GFDFFNKITN VSAVIKPYPK GDERKKACLS ALSEVTVQPG
   241  CSLPSNPEAI VLDVDYKSGT PMQSAAKAPY LAKFKVKRCG VSELEKEGLR CRSDSEDECS
   301  TQEADGQKIS WQAAIFKLGD DCRQKSYWGA RMPTDRILRL PASQDMLALQ IIDLFKNIFQ
   361  LVGLDLFVFP YRVVATAPGC GVIECIPDCT SRDQLGRQTD FGMYDYFTRQ YGDESTLAFQ
   421  QARYNFIRSM AAYSLLLFLL QIKDRHNGNI MLDKKGHIIH IDFGFMFESS PGGNLGWEPD
   481  IKLTDEMVMI MGGKMEATPF KWFMEMCVQA TWLCGEPGPY MDVVVSLVTI MLDTGLPCFR
   541  GQTIKLLKHR FSPNMTEREA ANFIMKVIQS CFLSNRSRTY NMIQYYQNDI PY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PI4KAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phosphatidylinositol phosphate biosynthetic process

Molecular functions

kinase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PI4KAP2 as an antibody target. Whether an autoantibody or antibody against PI4KAP2 could matter depends on whether native PI4KAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PI4KAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PI4KAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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