Seroatlas · Human Serome Atlas

PI4KAP1

Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

Also known as: PI4P1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8J0
Gene: PI4KAP1
Canonical length: 262 aa

OverviewNCBI Gene

No narrative summary is available for PI4KAP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q8N8J0|PI4KAP1
     1  MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE IAKYCSSDQV
    61  EIFSSLLQRS MSLNIGGAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK
   121  IYSTAFDYFS CPPKFPTQGE KRLREDISIM IKFWTAMFSD KKYLTASQLV PPADIGDLRE
   181  QLVEENTGSL SGPAKDFYQR EFDFFNKITN VSAVIKPYPK GDQRKKACLS ALSEVTVQPG
   241  CSLPSNPEAI VLDVDYKSGT PM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PI4KAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PI4KAP1 as an antibody target. Whether an autoantibody or antibody against PI4KAP1 could matter depends on whether native PI4KAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PI4KAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PI4KAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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