Seroatlas · Human Serome Atlas

PI4K2B

Phosphatidylinositol 4-kinase type 2-beta

Also known as: FLJ11105, P4K2B_HUMAN, PI4KIIB, PIK42B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCG2
Gene: PI4K2B
Ensembl: ENSG00000038210
Chromosome: 4
Canonical length: 481 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q8TCG2|PI4K2B
     1  MEDPSEPDRL ASADGGSPEE EEDGEREPLL PRIAWAHPRR GAPGSAVRLL DAAGEEGEAG
    61  DEELPLPPGD VGVSRSSSAE LDRSRPAVSV TIGTSEMNAF LDDPEFADIM LRAEQAIEVG
   121  IFPERISQGS SGSYFVKDPK RKIIGVFKPK SEEPYGQLNP KWTKYVHKVC CPCCFGRGCL
   181  IPNQGYLSEA GAYLVDNKLH LSIVPKTKVV WLVSETFNYN AIDRAKSRGK KYALEKVPKV
   241  GRKFHRIGLP PKIGSFQLFV EGYKEAEYWL RKFEADPLPE NIRKQFQSQF ERLVILDYII
   301  RNTDRGNDNW LVRYEKQKCE KEIDHKESKW IDDEEFLIKI AAIDNGLAFP FKHPDEWRAY
   361  PFHWAWLPQA KVPFSEEIRN LILPYISDMN FVQDLCEDLY ELFKTDKGFD KATFESQMSV
   421  MRGQILNLTQ ALRDGKSPFQ LVQIPCVIVE RSQGGSQGRI VHLSNSFTQT VNCRKPFFSS
   481  W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PI4K2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

liver: 54 nTPM
duodenum: 37 nTPM
small intestine: 30 nTPM
thyroid gland: 23 nTPM
salivary gland: 22 nTPM
stomach: 21 nTPM

Single-cell type

neutrophil progenitors: 101 nCPM
sertoli cells: 96 nCPM
hepatocytes: 81 nCPM
choroid plexus epithelial cells: 73 nCPM
lacrimal acinar cells: 73 nCPM
cytotrophoblasts: 72 nCPM

Immune cell

basophil: 5.3 nTPM
T-reg: 3.5 nTPM
eosinophil: 3.4 nTPM
neutrophil: 1.7 nTPM
gdT-cell: 1.5 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

choroid plexus: 10 nTPM
white matter: 8.9 nTPM
spinal cord: 7.4 nTPM
medulla oblongata: 7.3 nTPM
hypothalamus: 6.8 nTPM
pons: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.24
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PI4K2B as an antibody target. Whether an autoantibody or antibody against PI4K2B could matter depends on whether native PI4K2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PI4K2B is annotated at the cell surface, where native PI4K2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PI4K2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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