Seroatlas · Human Serome Atlas

PHYHIPL

Phytanoyl-CoA hydroxylase-interacting protein-like

Also known as: Em:AC025038.1, KIAA1796, PHIPL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FC7
Gene: PHYHIPL
Ensembl: ENSG00000165443
Chromosome: 10
Canonical length: 376 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q96FC7|PHYHIPL
     1  MEVPRLDHAL NSPTSPCEEV IKNLSLEAIQ LCDRDGNKSQ DSGIAEMEEL PVPHNIKISN
    61  ITCDSFKISW EMDSKSKDRI THYFIDLNKK ENKNSNKFKH KDVPTKLVAK AVPLPMTVRG
   121  HWFLSPRTEY TVAVQTASKQ VDGDYVVSEW SEIIEFCTAD YSKVHLTQLL EKAEVIAGRM
   181  LKFSVFYRNQ HKEYFDYVRE HHGNAMQPSV KDNSGSHGSP ISGKLEGIFF SCSTEFNTGK
   241  PPQDSPYGRY RFEIAAEKLF NPNTNLYFGD FYCMYTAYHY VILVIAPVGS PGDEFCKQRL
   301  PQLNSKDNKF LTCTEEDGVL VYHHAQDVIL EVIYTDPVDL SVGTVAEITG HQLMSLSTAN
   361  AKKDPSCKTC NISVGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHYHIPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 51 nTPM
midbrain: 46 nTPM
spinal cord: 45 nTPM
hypothalamus: 35 nTPM
amygdala: 34 nTPM
hippocampal formation: 32 nTPM

Single-cell type

bergmann glia: 805 nCPM
oligodendrocytes: 538 nCPM
oligodendrocyte progenitor cells: 498 nCPM
late spermatids: 421 nCPM
müller glia: 405 nCPM
astrocytes: 377 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 104 nTPM
spinal cord: 100 nTPM
medulla oblongata: 97 nTPM
hypothalamus: 86 nTPM
midbrain: 77 nTPM
cerebellum: 76 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.82
gnomAD missense Z: 1.64
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHYHIPL as an antibody target. Whether an autoantibody or antibody against PHYHIPL could matter depends on whether native PHYHIPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHYHIPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHYHIPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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