PHYHIP
Phytanoyl-CoA hydroxylase-interacting protein
Also known as: DYRK1AP3, KIAA0273, PAHX-AP, PHYIP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q92561
- Gene
- PHYHIP
- Ensembl
- ENSG00000168490
- Chromosome
- 8
- Canonical length
- 330 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
Enables protein tyrosine kinase binding activity. Involved in protein localization. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
330 residues, UniProt reviewed canonical sequence.
>Q92561|PHYHIP
1 MELLSTPHSI EINNITCDSF RISWAMEDSD LERVTHYFID LNKKENKNSN KFKHRDVPTK
61 LVAKAVPLPM TVRGHWFLSP RTEYSVAVQT AVKQSDGEYL VSGWSETVEF CTGDYAKEHL
121 AQLQEKAEQI AGRMLRFSVF YRNHHKEYFQ HARTHCGNML QPYLKDNSGS HGSPTSGMLH
181 GVFFSCNTEF NTGQPPQDSP YGRWRFQIPA QRLFNPSTNL YFADFYCMYT AYHYAILVLA
241 PKGSLGDRFC RDRLPLLDIA CNKFLTCSVE DGELVFRHAQ DLILEIIYTE PVDLSLGTLG
301 EISGHQLMSL STADAKKDPS CKTCNISVGRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PHYHIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 347 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 347 nTPM
- basal ganglia: 308 nTPM
- cerebral cortex: 286 nTPM
- hippocampal formation: 184 nTPM
- amygdala: 141 nTPM
- hypothalamus: 73 nTPM
Single-cell type
- podocytes: 112 nCPM
- brain excitatory neurons: 89 nCPM
- brain inhibitory neurons: 63 nCPM
- corticotrophs: 44 nCPM
- smooth muscle cells: 39 nCPM
- other brain neurons: 31 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 550 nTPM
- hippocampal formation: 544 nTPM
- basal ganglia: 490 nTPM
- white matter: 382 nTPM
- amygdala: 321 nTPM
- cerebellum: 311 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.44
- gnomAD pLI
- 0.86
- gnomAD missense Z
- 3.26
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PHYHIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PHYHIP as an antibody target. Whether an autoantibody or antibody against PHYHIP could matter depends on whether native PHYHIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PHYHIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PHYHIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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