PHYHD1
Phytanoyl-CoA dioxygenase domain-containing protein 1
Also known as: MGC16638, PHYD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5SRE7
- Gene
- PHYHD1
- Ensembl
- ENSG00000175287
- Chromosome
- 9
- Canonical length
- 291 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles
OverviewNCBI Gene
Enables 2-oxoglutarate-dependent dioxygenase activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
291 residues, UniProt reviewed canonical sequence.
>Q5SRE7|PHYHD1
1 MACLSPSQLQ KFQQDGFLVL EGFLSAEECV AMQQRIGEIV AEMDVPLHCR TEFSTQEEEQ
61 LRAQGSTDYF LSSGDKIRFF FEKGVFDEKG NFLVPPEKSI NKIGHALHAH DPVFKSITHS
121 FKVQTLARSL GLQMPVVVQS MYIFKQPHFG GEVSPHQDAS FLYTEPLGRV LGVWIAVEDA
181 TLENGCLWFI PGSHTSGVSR RMVRAPVGSA PGTSFLGSEP ARDNSLFVPT PVQRGALVLI
241 HGEVVHKSKQ NLSDRSRQAY TFHLMEASGT TWSPENWLQP TAELPFPQLY TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PHYHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.23
- Highest tissue expression
- 81 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 81 nTPM
- liver: 78 nTPM
- pancreas: 67 nTPM
- kidney: 49 nTPM
- midbrain: 45 nTPM
- amygdala: 43 nTPM
Single-cell type
- rod photoreceptor cells: 104 nCPM
- bergmann glia: 75 nCPM
- cone photoreceptor cells: 73 nCPM
- astrocytes: 57 nCPM
- leydig cells: 53 nCPM
- müller glia: 44 nCPM
Immune cell
- plasmacytoid DC: 13 nTPM
- memory B-cell: 2.9 nTPM
- NK-cell: 2 nTPM
- naive CD8 T-cell: 1.9 nTPM
- basophil: 1.7 nTPM
- myeloid DC: 1.7 nTPM
Brain region
- midbrain: 63 nTPM
- thalamus: 56 nTPM
- medulla oblongata: 55 nTPM
- spinal cord: 55 nTPM
- white matter: 54 nTPM
- hypothalamus: 53 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.23
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PHYHD1 as an antibody target. Whether an autoantibody or antibody against PHYHD1 could matter depends on whether native PHYHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PHYHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PHYHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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