Seroatlas · Human Serome Atlas

PHTF2

Protein PHTF2

Also known as: DKFZp434D166, PHTF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3S3
Gene: PHTF2
Ensembl: ENSG00000006576
Chromosome: 7
Canonical length: 785 aa
Protein class: Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

785 residues, UniProt reviewed canonical sequence.

>Q8N3S3|PHTF2
     1  MASKVTDAIV WYQKKEFLSV ATTAPGPQQV LPGYCQCSLK DQGLFIQCLI GAYDQQIWEK
    61  SVEQREIKFI KLGLRNKPKK TAHVKPDLID VDLVRGSAFA KAKPESPWTS LTRKGIVRVV
   121  FFPFFFRWWL QVTSKVIFFW LLVLYLLQVA AIVLFCSTSS PHSIPLTEVI GPIWLMLLLG
   181  TVHCQIVSTR TPKPPLSTGG KRRRKLRKAA HLEVHREGDG SSTTDNTQEG AVQNHGTSTS
   241  HSVGTVFRDL WHAAFFLSGS KKAKNSIDKS TETDNGYVSL DGKKTVKSGE DGIQNHEPQC
   301  ETIRPEETAW NTGTLRNGPS KDTQRTITNV SDEVSSEEGP ETGYSLRRHV DRTSEGVLRN
   361  RKSHHYKKHY PNEDAPKSGT SCSSRCSSSR QDSESARPES ETEDVLWEDL LHCAECHSSC
   421  TSETDVENHQ INPCVKKEYR DDPFHQSHLP WLHSSHPGLE KISAIVWEGN DCKKADMSVL
   481  EISGMIMNRV NSHIPGIGYQ IFGNAVSLIL GLTPFVFRLS QATDLEQLTA HSASELYVIA
   541  FGSNEDVIVL SMVIISFVVR VSLVWIFFFL LCVAERTYKQ RLLFAKLFGH LTSARRARKS
   601  EVPHFRLKKV QNIKMWLSLR SYLKRRGPQR SVDVIVSSAF LLTISVVFIC CAQLLHVHEI
   661  FLDCHYNWEL VIWCISLTLF LLRFVTLGSE TSKKYSNTSI LLTEQINLYL KMEKKPNKKE
   721  ELTLVNNVLK LATKLLKELD SPFRLYGLTM NPLLYNITQV VILSAVSGVI SDLLGFNLKL
   781  WKIKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHTF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 104 nTPM
tongue: 51 nTPM
parathyroid gland: 25 nTPM
lymph node: 17 nTPM
tonsil: 17 nTPM
blood vessel: 16 nTPM

Single-cell type

myonuclei: 629 nCPM
platelets: 289 nCPM
mast cells: 274 nCPM
b-cells: 261 nCPM
pancreatic islet cells: 215 nCPM
t-cells: 206 nCPM

Immune cell

non-classical monocyte: 26 nTPM
basophil: 14 nTPM
intermediate monocyte: 12 nTPM
memory B-cell: 8.4 nTPM
T-reg: 8.3 nTPM
memory CD4 T-cell: 5.7 nTPM

Brain region

white matter: 20 nTPM
cerebral cortex: 18 nTPM
cerebellum: 16 nTPM
medulla oblongata: 14 nTPM
spinal cord: 14 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 2.29
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHTF2 as an antibody target. Whether an autoantibody or antibody against PHTF2 could matter depends on whether native PHTF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHTF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHTF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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