Seroatlas · Human Serome Atlas

PHPT1

14 kDa phosphohistidine phosphatase

Also known as: bA216L13.10, CGI-202, DKFZp564M173, HSPC141, PHP14, PHP14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRX4
Gene: PHPT1
Ensembl: ENSG00000054148
Chromosome: 9
Canonical length: 125 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q9NRX4|PHPT1
     1  MAVADLALIP DVDIDSDGVF KYVLIRVHSA PRSGAPAAES KEIVRGYKWA EYHADIYDKV
    61  SGDMQKQGCD CECLGGGRIS HQSQDKKIHV YGYSMAYGPA QHAISTEKIK AKYPDYEVTW
   121  ANDGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHPT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 412 nTPM

Expression across tissuesHPA

Tissue

tongue: 412 nTPM
skeletal muscle: 406 nTPM
heart muscle: 382 nTPM
amygdala: 256 nTPM
choroid plexus: 235 nTPM
midbrain: 223 nTPM

Single-cell type

late spermatids: 1,540 nCPM
epididymal principal cells: 652 nCPM
extravillous trophoblasts: 626 nCPM
enterocytes: 461 nCPM
migrating cytotrophoblasts: 458 nCPM
fallopian secretory cells: 442 nCPM

Immune cell

plasmacytoid DC: 427 nTPM
total PBMC: 325 nTPM
myeloid DC: 322 nTPM
intermediate monocyte: 319 nTPM
classical monocyte: 291 nTPM
memory B-cell: 242 nTPM

Brain region

white matter: 124 nTPM
cerebellum: 106 nTPM
hypothalamus: 102 nTPM
medulla oblongata: 94 nTPM
thalamus: 94 nTPM
basal ganglia: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Janus
Janus superfamily
Janus/Ocnus family (Ocnus)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHPT1 as an antibody target. Whether an autoantibody or antibody against PHPT1 could matter depends on whether native PHPT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHPT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHPT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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