Seroatlas · Human Serome Atlas

PHOSPHO1

Phosphoethanolamine/phosphocholine phosphatase

Also known as: PHOP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCT1
Gene: PHOSPHO1
Ensembl: ENSG00000173868
Chromosome: 17
Canonical length: 267 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments

OverviewNCBI Gene

Enables phosphocholine phosphatase activity; phosphoethanolamine phosphatase activity; and pyrophosphatase activity. Predicted to be involved in bone mineralization involved in bone maturation. Predicted to act upstream of or within endochondral ossification. Predicted to be located in cytosol. Predicted to be active in extracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q8TCT1|PHOSPHO1
     1  MSGCFPVSGL RCLSRDGRMA AQGAPRFLLT FDFDETIVDE NSDDSIVRAA PGQRLPESLR
    61  ATYREGFYNE YMQRVFKYLG EQGVRPRDLS AIYEAIPLSP GMSDLLQFVA KQGACFEVIL
   121  ISDANTFGVE SSLRAAGHHS LFRRILSNPS GPDARGLLAL RPFHTHSCAR CPANMCKHKV
   181  LSDYLRERAH DGVHFERLFY VGDGANDFCP MGLLAGGDVA FPRRGYPMHR LIQEAQKAEP
   241  SSFRASVVPW ETAADVRLHL QQVLKSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHOSPHO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

testis: 91 nTPM
bone marrow: 18 nTPM
spleen: 13 nTPM
placenta: 6 nTPM
cerebral cortex: 3.4 nTPM
appendix: 3.2 nTPM

Single-cell type

late spermatids: 2,845 nCPM
syncytiotrophoblasts: 344 nCPM
early spermatids: 227 nCPM
neutrophils: 41 nCPM
late primary spermatocytes: 37 nCPM
erythrocytes: 15 nCPM

Immune cell

neutrophil: 429 nTPM
eosinophil: 172 nTPM
non-classical monocyte: 1.8 nTPM
intermediate monocyte: 1.5 nTPM
total PBMC: 1.1 nTPM
classical monocyte: 0.6 nTPM

Brain region

medulla oblongata: 23 nTPM
hypothalamus: 21 nTPM
pons: 20 nTPM
spinal cord: 20 nTPM
cerebellum: 18 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.51
gnomAD missense Z: 1.17
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding
phosphatase activity
phosphoethanolamine phosphatase activity
pyrophosphatase activity
phosphocholine phosphatase activity

Cellular components

cytosol
extracellular matrix
extracellular vesicle
extracellular membrane-bounded organelle

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHOSPHO1 as an antibody target. Whether an autoantibody or antibody against PHOSPHO1 could matter depends on whether native PHOSPHO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHOSPHO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHOSPHO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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